7 results on '"Fenu G"'
Search Results
2. Combining HLA-DRB1-DQB1 and Mycobacterium Avium Subspecies Paratubercolosis (MAP) antibodies in Sardinian multiple sclerosis patients: associated or independent risk factors?
- Author
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Frau, J., primary, Cossu, D., additional, Sardu, C., additional, Mameli, G., additional, Coghe, G., additional, Lorefice, L., additional, Fenu, G., additional, Tranquilli, S., additional, Sechi, L. A., additional, Marrosu, M. G., additional, and Cocco, E., additional
- Published
- 2016
- Full Text
- View/download PDF
3. The Brief International Cognitive Assessment for Multiple Sclerosis (BICAMS): normative values with gender, age and education corrections in the Italian population
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Eleonora Cocco, Andrea Sturchio, Elisabetta Garofalo, G. B. Zimatore, Monica Falautano, Rosa Gemma Viterbo, Vittorio Martinelli, Ugo Nocentini, Ferdinando Ivano Ambra, Dawn Langdon, Maria Pia Amato, Maria Giovanna Marrosu, Monica Murgia, Nunzia Alessandra Losignore, Chiara Concetta Incerti, Emilio Portaccio, Maurizio Maddestra, Eleonora Minacapelli, Bahia Hakiki, Benedetta Goretti, Alessandra Lugaresi, Erika Pietrolongo, Giuseppe Fenu, Marilena Consalvo, Maria Trojano, Claudia Niccolai, Goretti B, Niccolai C, Hakiki B, Sturchio A, Falautano M, Eleonora M, Martinelli V, Incerti C, Nocentini U, Murgia M, Fenu G, Cocco E, Marrosu M, Garofalo E, Ambra F, Maddestra M, Consalvo M, Viterbo R, Trojano M, Losignore N, Zimatore G, Pietrolongo E, Lugaresi A, Langdon D, Portaccio E, and Amato M
- Subjects
Gerontology ,Adult ,Male ,Multiple Sclerosis ,Adolescent ,Clinical Neurology ,Neuropsychological Tests ,evaluation, cognitive, battery, multiple sclerosis ,Verbal learning ,BICAMS ,symbols.namesake ,Young Adult ,Reference Values ,medicine ,Humans ,Italian normative values ,Young adult ,Reliability (statistics) ,Aged ,Assessment tool ,Cognitive impairment ,Multiple sclerosis ,Cognition Disorders ,Female ,Healthy Volunteers ,Italy ,Middle Aged ,Reproducibility of Results ,cognitive impairment ,assessment tool ,Cognition ,General Medicine ,medicine.disease ,Pearson product-moment correlation coefficient ,Test (assessment) ,symbols ,Normative ,Settore MED/26 - Neurologia ,Neurology (clinical) ,Psychology ,Research Article - Abstract
Background BICAMS (Brief International Cognitive Assessment for Multiple Sclerosis) has been recently developed as brief, practical and universal assessment tool for cognitive impairment in MS subjects. It includes the Symbol Digit Modalities Test (SDMT), the California Verbal Learning Test-2 (CVLT2) and the Brief Visuospatial Memory Test–Revised (BVMT-R) . In this study we aimed at gathering regression based normative data for the BICAMS battery in the Italian population. Methods Healthy subjects were consecutively recruited among patient friends and relatives. Corrections for demographics were calculated using multivariable linear regression models. Test-retest reliability was assessed using the Pearson correlation coefficient. Results The BICAMS battery was administered to 273 healthy subjects (180 women, mean age 38.9 ± 13.0 years, mean education 14.9 ± 3.0 years). Test-retest reliability was good for all the tests. Conclusions The study provided normative data of the BICAMS for the Italian population confirming good test-retest reliability which can facilitate the use of the battery in clinical practice, also for longitudinal patient assessments.
- Published
- 2014
4. A cross-sectional and longitudinal study evaluating brain volumes, RNFL, and cognitive functions in MS patients and healthy controls.
- Author
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Frau J, Fenu G, Signori A, Coghe G, Lorefice L, Barracciu MA, Sechi V, Cabras F, Badas M, Marrosu MG, and Cocco E
- Subjects
- Adult, Cognitive Dysfunction etiology, Cross-Sectional Studies, Female, Humans, Longitudinal Studies, Magnetic Resonance Imaging, Male, Middle Aged, Multiple Sclerosis, Relapsing-Remitting complications, Tomography, Optical Coherence, Brain diagnostic imaging, Cognitive Dysfunction physiopathology, Multiple Sclerosis, Relapsing-Remitting diagnostic imaging, Multiple Sclerosis, Relapsing-Remitting physiopathology, Nerve Fibers pathology, Retina diagnostic imaging
- Abstract
Background: The principal biomarker of neurodegeneration in multiple sclerosis (MS) is believed to be brain volume, which is associated with cognitive functions and retinal nerve fibre layer (RNFL). A cross-sectional and longitudinal assessment of the relationship between RNFL, cognitive functions and brain volume., Methods: At baseline, relapsing patients and healthy controls underwent 1.5 T MRI to estimate the normalized volume of brain (NBV), grey (NGV), white (NWV) and peripheral grey (pNGV) matter. Cognitive functions were evaluated by BICAMS, RNFL by Spectral-Domain OCT. Patients were re-evaluated after 12 months., Results: Cognitive functions, brain volume, and RNFL differed between the group of 66 patients and that of 16 healthy controls. In the MS group, at baseline, an association was found between: p-NGV and symbol-digit (SDMT) (p = 0.022); temporal-RNFL and NBV (p = 0.007), NWV (p = 0.012), NGV (p = 0.048), and p-NGV (p = 0.021); papillo-macular bundle-RNFL and NBV (p = 0.013), NWV (p = 0.02), NGV (p = 0.049), and p-NGV (p = 0.032). Over the observational period, we found a reduction of brain volume (p < 0.001), average-RNFL (p = 0.001), temporal-RNFL (p = 0.006), and papillo-macular bundle-RNFL (p = 0.009). No association was found between OCT, MRI, and cognitive changes., Conclusions: Brain volume, cognitive functions, and RNFL are continuous measures of different neurodegenerative aspects. BICAMS and OCT have low costs and can be easily used in clinical practice to monitor neurodegeneration.
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- 2018
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- View/download PDF
5. A comparison of the brief international cognitive assessment for multiple sclerosis and the brief repeatable battery in multiple sclerosis patients.
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Niccolai C, Portaccio E, Goretti B, Hakiki B, Giannini M, Pastò L, Righini I, Falautano M, Minacapelli E, Martinelli V, Incerti C, Nocentini U, Fenu G, Cocco E, Marrosu MG, Garofalo E, Ambra FI, Maddestra M, Consalvo M, Viterbo RG, Trojano M, Losignore NA, Zimatore GB, Pietrolongo E, Lugaresi A, Pippolo L, Roscio M, Ghezzi A, Castellano D, Stecchi S, and Amato MP
- Subjects
- Adult, Cognition Disorders etiology, Female, Humans, Male, Middle Aged, Multiple Sclerosis complications, Cognition Disorders diagnosis, Multiple Sclerosis diagnosis, Neuropsychological Tests standards, Psychometrics instrumentation
- Abstract
Background: Recently, a Brief International Cognitive Assessment for Multiple Sclerosis (BICAMS) has been developed as an international and standardized brief cognitive test, which is easily performed in everyday clinical practice for neuropsychological assessment in multiple sclerosis (MS). However, we need to gather more information about this tool compared to other neuropsychological batteries. The aim of our study is to compare the performance of BICAMS and Brief Repeatable Battery (BRB) in MS subjects., Methods: Tests of the BRB and BICAMS were administered to MS patients recruited from 11 Italian MS centres. Cognitive impairment (CI) was defined as the failure on at least two tests (scores below the fifth percentile) on the BRB and as the failure on at least one test of the BICAMS. The agreement between the performances on the two batteries was assessed through Cohen's K statistic. Finally we calculated the effects sizes for each test of the two batteries using Cohen's d., Results: The two batteries were administered to 192 MS patients (142 women, 50 men; mean age 41.4 ± 10.8 years, mean education 12.3 ± 3.5 years). Mean scores of patients were lower compared to those of healthy subjects in all the cognitive measures examined. Forty-six MS patients were identified as impaired and 48 as unimpaired on both of the batteries, when the Symbol Digit Modalities Test (SDMT) was included in the analysis. Cohen's K statistic was 0.46 which corresponds to a moderate accord. If the SDMT was excluded from the BRB, 37 MS patients were identified as impaired and 57 as unimpaired on both of the batteries. Cohen's K statistic was 0.3 which corresponds to a poor accord. The SDMT, the Paced Auditory Serial Addition Test (PASAT) 3 and 2 yielded higher d values (SDMT 0.83, PASAT 3 0.65, PASAT 2 0.84)., Conclusions: This study confirms the feasibility of BICAMS in everyday clinical practice for the identification of CI and highlights the good psychometric properties of the SDMT.
- Published
- 2015
- Full Text
- View/download PDF
6. The Brief International Cognitive Assessment for Multiple Sclerosis (BICAMS): normative values with gender, age and education corrections in the Italian population.
- Author
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Goretti B, Niccolai C, Hakiki B, Sturchio A, Falautano M, Minacapelli E, Martinelli V, Incerti C, Nocentini U, Murgia M, Fenu G, Cocco E, Marrosu MG, Garofalo E, Ambra FI, Maddestra M, Consalvo M, Viterbo RG, Trojano M, Losignore NA, Zimatore GB, Pietrolongo E, Lugaresi A, Langdon D, Portaccio E, and Amato MP
- Subjects
- Adolescent, Adult, Aged, Cognition Disorders etiology, Female, Healthy Volunteers, Humans, Italy, Male, Middle Aged, Multiple Sclerosis complications, Reference Values, Reproducibility of Results, Young Adult, Cognition Disorders diagnosis, Multiple Sclerosis diagnosis, Neuropsychological Tests standards
- Abstract
Background: BICAMS (Brief International Cognitive Assessment for Multiple Sclerosis) has been recently developed as brief, practical and universal assessment tool for cognitive impairment in MS subjects. It includes the Symbol Digit Modalities Test (SDMT), the California Verbal Learning Test-2 (CVLT2) and the Brief Visuospatial Memory Test-Revised (BVMT-R) . In this study we aimed at gathering regression based normative data for the BICAMS battery in the Italian population., Methods: Healthy subjects were consecutively recruited among patient friends and relatives. Corrections for demographics were calculated using multivariable linear regression models. Test-retest reliability was assessed using the Pearson correlation coefficient., Results: The BICAMS battery was administered to 273 healthy subjects (180 women, mean age 38.9 ± 13.0 years, mean education 14.9 ± 3.0 years). Test-retest reliability was good for all the tests., Conclusions: The study provided normative data of the BICAMS for the Italian population confirming good test-retest reliability which can facilitate the use of the battery in clinical practice, also for longitudinal patient assessments.
- Published
- 2014
- Full Text
- View/download PDF
7. What do multiple sclerosis patients and their caregivers perceive as unmet needs?
- Author
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Lorefice L, Mura G, Coni G, Fenu G, Sardu C, Frau J, Coghe G, Melis M, Marrosu MG, and Cocco E
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- Adolescent, Adult, Female, Humans, Male, Middle Aged, Surveys and Questionnaires, Young Adult, Caregivers psychology, Health Services Needs and Demand, Multiple Sclerosis psychology, Multiple Sclerosis therapy, Patient Satisfaction, Social Support
- Abstract
Background: Multiple sclerosis (MS) has a major impact on the physical, psychological and social life of patients and their families. The aim of this study was to evaluate the different perceptions of patients and caregivers about management of MS, particularly about the same items, to gather information to ameliorate the care of patients., Methods: We evaluated what MS patients and caregivers perceive as unmet needs and compared patients' opinions with caregivers' opinions using a multidimensional questionnaire. The questionnaire was specifically designed for the study, taking into account different aspects of the global care perceived by patients and care givers, such as information about MS, medical treatment and rehabilitation, patients' relationships with medical staff and their psychological and social life., Results: We administered the questionnaire to 497 patients and 206 caregivers. Results showed that the majority of participants were satisfied with medical staff but expressed a desire that staff be more forthcoming with information about MS. As for medical treatment concerns, more patients found there to be useful a multidisciplinary approach than caregivers did. Both required psychological support for patients but patients felt a greater need for it at the time of diagnosis, whereas caregivers felt it was required post-diagnosis. Both reported significant strains on patient relationships at work but no effect on other social interactions., Conclusions: A better understanding of MS patient needs, starting from the point of view of patients and caregivers, could have a great impact on quality of life and on management of the disease.
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- 2013
- Full Text
- View/download PDF
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