1. Fast reproducible identification and large-scale databasing of individual functional cognitive networks
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Antoinette Jobert, Jean-Baptiste Poline, Denis Le Bihan, Stanislas Dehaene, Philippe Pinel, Julien Serres, Sébastien Mériaux, Bertrand Thirion, Neuroimagerie cognitive (LCogn), Université Paris-Sud - Paris 11 (UP11)-Commissariat à l'énergie atomique et aux énergies alternatives (CEA)-Institut National de la Santé et de la Recherche Médicale (INSERM), Laboratoire de Neuroimagerie Assistée par Ordinateur (LNAO), Commissariat à l'énergie atomique et aux énergies alternatives (CEA), Modelling brain structure, function and variability based on high-field MRI data (PARIETAL), Service NEUROSPIN (NEUROSPIN), Université Paris-Saclay-Direction de Recherche Fondamentale (CEA) (DRF (CEA)), Commissariat à l'énergie atomique et aux énergies alternatives (CEA)-Commissariat à l'énergie atomique et aux énergies alternatives (CEA)-Université Paris-Saclay-Direction de Recherche Fondamentale (CEA) (DRF (CEA)), Commissariat à l'énergie atomique et aux énergies alternatives (CEA)-Commissariat à l'énergie atomique et aux énergies alternatives (CEA)-Inria Saclay - Ile de France, Institut National de Recherche en Informatique et en Automatique (Inria)-Institut National de Recherche en Informatique et en Automatique (Inria), Commissariat à l'énergie atomique et aux énergies alternatives (CEA)-Commissariat à l'énergie atomique et aux énergies alternatives (CEA), Institut des Sciences du Mouvement Etienne Jules Marey (ISM), Aix Marseille Université (AMU)-Centre National de la Recherche Scientifique (CNRS), Collège de France - Chaire Psychologie cognitive expérimentale, Collège de France (CdF (institution)), Inria Saclay - Ile de France, Institut National de Recherche en Informatique et en Automatique (Inria)-Institut National de Recherche en Informatique et en Automatique (Inria)-Service NEUROSPIN (NEUROSPIN), Direction de Recherche Fondamentale (CEA) (DRF (CEA)), Commissariat à l'énergie atomique et aux énergies alternatives (CEA)-Commissariat à l'énergie atomique et aux énergies alternatives (CEA)-Université Paris-Saclay, Centre National de la Recherche Scientifique (CNRS)-Aix Marseille Université (AMU), Chaire Psychologie cognitive expérimentale, and BMC, Ed. more...
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Male ,Time Factors ,Visual perception ,Databases, Factual ,[SDV.IB.IMA]Life Sciences [q-bio]/Bioengineering/Imaging ,[INFO.INFO-IM] Computer Science [cs]/Medical Imaging ,MESH: Cognition ,computer.software_genre ,MESH: Magnetic Resonance Imaging ,Cognition ,0302 clinical medicine ,Reading (process) ,MESH: Brain Mapping ,media_common ,Brain Mapping ,0303 health sciences ,medicine.diagnostic_test ,General Neuroscience ,lcsh:QP351-495 ,Magnetic Resonance Imaging ,MESH: Photic Stimulation ,Female ,[SDV.NEU]Life Sciences [q-bio]/Neurons and Cognition [q-bio.NC] ,Psychology ,Natural language processing ,Research Article ,Adult ,media_common.quotation_subject ,MESH: Acoustic Stimulation ,lcsh:RC321-571 ,03 medical and health sciences ,Cellular and Molecular Neuroscience ,Functional neuroimaging ,medicine ,[INFO.INFO-IM]Computer Science [cs]/Medical Imaging ,Humans ,[SDV.NEU] Life Sciences [q-bio]/Neurons and Cognition [q-bio.NC] ,lcsh:Neurosciences. Biological psychiatry. Neuropsychiatry ,030304 developmental biology ,MESH: Humans ,business.industry ,MESH: Time Factors ,MESH: Adult ,Cognitive network ,Mental calculation ,MESH: Databases, Factual ,MESH: Male ,Comprehension ,lcsh:Neurophysiology and neuropsychology ,[SDV.IB.IMA] Life Sciences [q-bio]/Bioengineering/Imaging ,Acoustic Stimulation ,MESH: Nerve Net ,Artificial intelligence ,Nerve Net ,business ,Functional magnetic resonance imaging ,Neuroscience ,computer ,MESH: Female ,Photic Stimulation ,030217 neurology & neurosurgery - Abstract
Background Although cognitive processes such as reading and calculation are associated with reproducible cerebral networks, inter-individual variability is considerable. Understanding the origins of this variability will require the elaboration of large multimodal databases compiling behavioral, anatomical, genetic and functional neuroimaging data over hundreds of subjects. With this goal in mind, we designed a simple and fast acquisition procedure based on a 5-minute functional magnetic resonance imaging (fMRI) sequence that can be run as easily and as systematically as an anatomical scan, and is therefore used in every subject undergoing fMRI in our laboratory. This protocol captures the cerebral bases of auditory and visual perception, motor actions, reading, language comprehension and mental calculation at an individual level. Results 81 subjects were successfully scanned. Before describing inter-individual variability, we demonstrated in the present study the reliability of individual functional data obtained with this short protocol. Considering the anatomical variability, we then needed to correctly describe individual functional networks in a voxel-free space. We applied then non-voxel based methods that automatically extract main features of individual patterns of activation: group analyses performed on these individual data not only converge to those reported with a more conventional voxel-based random effect analysis, but also keep information concerning variance in location and degrees of activation across subjects. Conclusion This collection of individual fMRI data will help to describe the cerebral inter-subject variability of the correlates of some language, calculation and sensorimotor tasks. In association with demographic, anatomical, behavioral and genetic data, this protocol will serve as the cornerstone to establish a hybrid database of hundreds of subjects suitable to study the range and causes of variation in the cerebral bases of numerous mental processes. more...
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