1. Mucoadhesive film containing α-mangostin shows potential role in oral cancer treatment.
- Author
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Tangsuksan P, Chuerduangphui J, Takahashi Yupanqui C, Srichana T, Hitakomate E, Pientong C, Ekalaksananan T, and Nittayananta W
- Subjects
- Animals, Fruit, Humans, Mice, Garcinia mangostana, Mouth Neoplasms drug therapy, Xanthones pharmacology
- Abstract
Background: Oral cancer is often preceded by a mucosal lesion called an oral potentially malignant disorder (OPMD). Many plant-derived compounds are of value in medicine. The objectives of this study were to develop a soluble mucoadhesive film containing α-mangostin (α-MG), a compound extracted from the peel of mangosteen fruit, and determine its activities against oral cancer cells, against human papillomavirus type 16 (HPV-16) pseudovirus, and its anti-inflammatory properties., Methods: A soluble mucoadhesive film containing α-MG was prepared. Oral squamous carcinoma cell line (SCC25), murine macrophage cells (RAW264.7), and human gingival fibroblast cell line were cultured. Anticancer activity and viability of SCC25 cells in response to α-MG film solution were determined by MTT assay. HPV-16 pseudovirus was constructed and effects of the film solution on attachment and post-attachment steps of the infection were investigated. Anti-inflammatory activity was assessed by nitric oxide (NO) inhibition. Fibroblast cell migration was determined by in vitro scratch assay., Results: The soluble α-MG film showed cytotoxic effects on SCC25 cells in concentration > 125 µg/ml with IC
50 of 152.5 µg/ml. Antiviral activity against HPV-16 pseudovirus was observed at attachment step, but not at post-attachment step. The film also possessed a strong anti-inflammatory effect and promoted wound healing without cytotoxicity., Conclusions: Mucoadhesive film containing α-MG has a cytotoxic effect on oral squamous carcinoma cell line and an inhibitory effect on HPV-16 pseudovirus at attachment step. The α-MG film also shows a potent anti-inflammatory activity and enhances wound healing. Thus, the soluble α-MG film may have a potential role in treating oral cancer., (© 2021. The Author(s).)- Published
- 2021
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