1. Dyslipidemia and reference values for fasting plasma lipid concentrations in Danish/North-European White children and adolescents
- Author
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Torben Hansen, Lise Pedersen, Ulrik Lausten-Thomsen, Palle Skov Bratholm, Cilius Esmann Fonvig, Christine Bøjsøe, Jens-Christian Holm, Tenna Ruest Haarmark Nielsen, and Oluf Pedersen
- Subjects
Male ,Pediatric Obesity ,Pediatrics ,Denmark ,030204 cardiovascular system & hematology ,Overweight ,0302 clinical medicine ,Prevalence ,Dyslipidemias/blood ,Medicine ,Child ,education.field_of_study ,lcsh:RJ1-570 ,Fasting ,Lipids ,Europe ,Triglycerides/blood ,Cholesterol ,Cohort ,language ,Female ,medicine.symptom ,Research Article ,medicine.medical_specialty ,Adolescent ,European Continental Ancestry Group ,Population ,030209 endocrinology & metabolism ,Cholesterol/blood ,White People ,Childhood obesity ,Europe/epidemiology ,Reference values ,Danish ,Young Adult ,03 medical and health sciences ,Journal Article ,Humans ,Obesity ,education ,Triglycerides ,Dyslipidemias ,business.industry ,lcsh:Pediatrics ,Odds ratio ,medicine.disease ,Denmark/epidemiology ,language.human_language ,Pediatric Obesity/blood ,Cross-Sectional Studies ,Logistic Models ,Case-Control Studies ,Pediatrics, Perinatology and Child Health ,business ,Biomarkers ,Biomarkers/blood ,Dyslipidemia - Abstract
Background Dyslipidemia is reported in 27 − 43% of children and adolescents with overweight/obesity and tracks into adulthood, increasing the risk of cardiovascular morbidity. Cut-off values for fasting plasma lipid concentrations are typically set at fixed levels throughout childhood. The objective of this cross-sectional study was to generate fasting plasma lipid references for a Danish/North-European White population-based cohort of children and adolescents, and investigate the prevalence of dyslipidemia in this cohort as well as in a cohort with overweight/obesity. Methods A population-based cohort of 2141 (1275 girls) children and adolescents aged 6 − 19 (median 11.5) years was recruited from 11 municipalities in Denmark. Additionally, a cohort of children and adolescents of 1421 (774 girls) with overweight/obesity aged 6 − 19 years (median 11.8) was recruited for the study. Height, weight, and fasting plasma lipid concentrations were measured on all participants. Smoothed reference curves and percentiles were generated using the Generalized Additive Models for Location Scale and Shape package in the statistical software R. Results In the population-based cohort, plasma concentrations of total cholesterol (TC) (P
- Published
- 2017
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