1. The footprint of SARS-COV-2 infection in neonatal late sepsis.
- Author
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Jamali Z, Mohammadpour N, Sinaei R, Jafari M, Sabzevari F, and Hasannejad M
- Subjects
- Male, Female, Humans, Infant, Newborn, Child, Adolescent, SARS-CoV-2, RNA, Viral, Cross-Sectional Studies, COVID-19, Neonatal Sepsis diagnosis, Sepsis diagnosis
- Abstract
Background: Predicting and finding the viral agents responsible for neonatal late-sepsis has always been challenging., Method: In this cross-sectional study, which has been done from September 2020 to December 2022, 145 hospitalized neonates suspected to late-onset sepsis alongside routine sepsis workup, were also evaluated for severe acute respiratory syndrome-coronavirus-2 (SARS-COV-2) infection, by nasopharyngeal real-time polymerase chain reaction (RT-PCR) or serological tests., Result: 145 neonates including 81 girls and 64 boys with a mean age of 12.3 ± 5.9 days and an average hospitalization stay of 23.1 ± 15.4 days were enrolled in the study. While 76.6% of them had negative bacterial culture, 63 patients (43.4%) showed evidence of SARS-COV-2 infection in RT-PCR or serology tests. None of the underlying factors including gender, age, and laboratory investigation had a significant relationship with SARS-COV-2 infection. Similarly, the outcomes of death and length of hospitalization were not different between the two groups with positive and negative SARS-COV-2 RT-PCR (P < 0.05). There was only a significant relationship between radiological changes including reticulonodular pattern, consolidation, pleural effusion, and different types of infiltrations and SARS-COV2 infection., Conclusion: Considering the widespread of coronavirus disease 2019 (COVID-19) in newborns, it seems logical to investigate the SARS-COV-2 infection in late-sepsis., (© 2024. The Author(s).)
- Published
- 2024
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