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Your search keyword '"Kurt Kletter"' showing total 5 results
Start Over Author "Kurt Kletter" Journal bmc pharmacology
5 results on '"Kurt Kletter"'

1. In vivo dose finding of tariquidar using (R)-[11C]verapamil μPET

Author

Rudolf Karch, Claudia Kuntner, Maria Zsebedics, Herbert Kvaternik, Markus Müller, Wolfgang Löscher, Jens P. Bankstahl, Thomas Wanek, Aiman Abrahim, Oliver Langer, Johann Stanek, and Kurt Kletter

Subjects
Pharmacology, medicine.diagnostic_test, business.industry, Tariquidar, Pharmacology toxicology, Effective dose (pharmacology), Dose finding, In vivo, Positron emission tomography, medicine, Verapamil, Pharmacology (medical), business, medicine.drug
Published
2007
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2. P-Glycoprotein inhibition at the blood-brain barrier visualized with (R)-[11C]verapamil μPET

Author

Markus Müller, Jens P. Bankstahl, Johann Stanek, Aiman Abrahim, Rudolf Karch, Maria Zsebedics, Herbert Kvaternik, Thomas Wanek, Oliver Langer, Claudia Kuntner, Kurt Kletter, and Wolfgang Löscher

Subjects
Pharmacology, Clinical pharmacology, biology, business.industry, fungi, education, Pharmacology toxicology, Pharmacy, Blood–brain barrier, humanities, law.invention, medicine.anatomical_structure, law, medicine, biology.protein, Verapamil, Pharmacology (medical), business, health care economics and organizations, geographic locations, medicine.drug, P-glycoprotein
Abstract

Address: 1Department of Radiopharmaceuticals, ARC GmbH, Seibersdorf, Austria, 2Department of Clinical Pharmacology, Medical University of Vienna, Austria, 3Department of Medical Computer Sciences, Medical University of Vienna, Austria, 4Department of Nuclear Medicine, Medical University of Vienna, Austria and 5Department of Pharmacology, Toxicology and Pharmacy, School of Veterinary Medicine Hannover, Germany

Published
2007
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3. Decreased blood-brain barrier P-glycoprotein function with aging

Author

Claudia C. Wagner, Aiman Abrahim, Markus Müller, Martin Bauer, Oliver Langer, Rudolf Karch, and Kurt Kletter

Subjects
Pharmacology, Pathology, medicine.medical_specialty, biology, business.industry, Endogeny, Blood–brain barrier, Membrane, medicine.anatomical_structure, nervous system, In vivo, Meeting Abstract, cardiovascular system, biology.protein, Biophysics, Medicine, Verapamil, Pharmacology (medical), Efflux, business, Distribution Volume, medicine.drug, P-glycoprotein
Abstract

P-glycoprotein (P-gp) acts at the blood-brain barrier (BBB) as an active cell membrane efflux pump for several endogenous and exogenous compounds. The P-gp substrate (R)-[11C]verapamil (VPM) can be used to measure P-gp-mediated transport at the BBB in vivo with positron emission tomography (PET). The distribution volume (DV) of VPM has been shown to inversely reflect P-gp function in the BBB [1].

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4. A combined accelerator mass spectrometry/positron emission tomography microdose study to assess the plasma and brain tissue pharmacokinetics of 11C- and 14C-labelled verapamil in healthy volunteers

Author

Kurt Kletter, Marie Simpson, Markus Müller, Graham Lappin, Martin Bauer, Aiman Abrahim, Markus Zeitlinger, Claudia C. Wagner, Oliver Langer, Rudolf Karch, and Thomas Feurstein

Subjects
Pharmacology, medicine.diagnostic_test, business.industry, Pharmacology toxicology, Brain tissue, Pharmacokinetics, MicroDose, Positron emission tomography, Healthy volunteers, Meeting Abstract, medicine, Verapamil, Pharmacology (medical), business, medicine.drug, Accelerator mass spectrometry
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5. Metabolism of (R)-[11C]verapamil in epilepsy patients

Author

Aiman Abrahim, Oliver Langer, Kurt Kletter, Martin Bauer, Rudolf Karch, Gert Luurtsema, Christoph Baumgartner, and Markus Müller

Subjects
Pharmacology, Epilepsy, business.industry, Pharmacology toxicology, Medicine, Verapamil, Pharmacology (medical), Metabolism, business, medicine.disease, medicine.drug
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