1. Effect of serum progesterone on human chorionic gonadotropin trigger day / metaphase II oocyte ratio on pregnancy and neonatal outcomes in women undergoing ICSI cycle.
- Author
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Huang, Li-Juan, Wan, Qi, Li, Tian, Lv, Xing-Yu, Geng, Li-Hong, He, Qi-Qi, Zhong, Zhao-Hui, Li, Yuan, and Tang, Xiao-Jun
- Subjects
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PREGNANCY outcomes , *CHORIONIC gonadotropins , *INTRACYTOPLASMIC sperm injection , *OVUM , *PROGESTERONE , *HUMAN artificial insemination - Abstract
Background: The serum progesterone on human chorionic gonadotropin trigger day / metaphase II oocyte (P/MII) ratio might be a more predictable indicator of pregnancy and neonatal outcomes as compare to P/estradiol (E2) or P alone. Hence, we conducted a larger population study to compare the pregnancy and neonatal outcomes in the low and high P/MII ratio. Methods: A retrospective, single-center, larger population cohort study between January 2015 and August 2021. Calculate the threshold effect of P/MII ratio on clinical pregnancy rate according to the construct smooth curve fitting. Divide data into two groups by threshold for comparison. Results: 3566 fresh ICSI-ET cycles were included, in which 929 singleton delivery and 676 twin deliveries. Compare to P/MII ≤ 0.367 group, it indicated that the P/MII > 0.367 group had a lower clinical pregnancy rate and live birth rate, furthermore, a significantly higher rate of LBW and SGA were observed in the singleton and twin deliveries. No deleterious impact of high P/MII ratio on embryo quality and undesirable pregnancy outcomes was shown. Conclusions: When P/MII is higher than 0.367, may have adverse impacts on pregnancy and neonatal outcomes for ICSI cycle. [ABSTRACT FROM AUTHOR]
- Published
- 2023
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