1. Comparative epidemiology of gestational diabetes in ethnic Chinese from Shanghai birth cohort and growing up in Singapore towards healthy outcomes cohort.
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Loo, Evelyn Xiu Ling, Zhang, Yuqing, Yap, Qai Ven, Yu, Guoqi, Soh, Shu E, Loy, See Ling, Lau, Hui Xing, Chan, Shiao-Yng, Shek, Lynette Pei-Chi, Luo, Zhong-Cheng, Yap, Fabian Kok Peng, Tan, Kok Hian, Chong, Yap Seng, Zhang, Jun, and Eriksson, Johan Gunnar
- Subjects
GESTATIONAL diabetes ,PREGNANCY complications ,MATERNAL health ,ADVERSE health care events ,DISEASE prevalence ,GLUCOSE tolerance tests ,CHINESE women ,LIFESTYLES & health - Abstract
Background: Gestational diabetes mellitus (GDM) has been associated with adverse health outcomes for mothers and offspring. Prevalence of GDM differs by country/region due to ethnicity, lifestyle and diagnostic criteria. We compared GDM rates and risk factors in two Asian cohorts using the 1999 WHO and the International Association of Diabetes and Pregnancy Study Groups (IADPSG) criteria.Methods: The Shanghai Birth Cohort (SBC) and the Growing Up in Singapore Towards healthy Outcomes (GUSTO) cohort are prospective birth cohorts. Information on sociodemographic characteristics and medical history were collected from interviewer-administered questionnaires. Participants underwent a 2-h 75-g oral glucose tolerance test at 24-28 weeks gestation. Logistic regressions were performed.Results: Using the 1999 WHO criteria, the prevalence of GDM was higher in GUSTO (20.8%) compared to SBC (16.6%) (p = 0.046). Family history of hypertension and alcohol consumption were associated with higher odds of GDM in SBC than in GUSTO cohort while obesity was associated with higher odds of GDM in GUSTO. Using the IADPSG criteria, the prevalence of GDM was 14.3% in SBC versus 12.0% in GUSTO. A history of GDM was associated with higher odds of GDM in GUSTO than in SBC, while being overweight, alcohol consumption and family history of diabetes were associated with higher odds of GDM in SBC.Conclusions: We observed several differential risk factors of GDM among ethnic Chinese women living in Shanghai and Singapore. These findings might be due to heterogeneity of GDM reflected in diagnostic criteria as well as in unmeasured genetic, lifestyle and environmental factors. [ABSTRACT FROM AUTHOR]- Published
- 2021
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