1. Exploratory analysis of obsessive compulsive symptom dimensions in children and adolescents: a Prospective follow-up study
- Author
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Catalina Betancur, Richard Delorme, Arnaud Bille, Flavie Mathieu, Marion Leboyer, Nadia Chabane, Marie Christine Mouren-Simeoni, Neurobiologie et Psychiatrie, Université Pierre et Marie Curie - Paris 6 (UPMC)-Institut National de la Santé et de la Recherche Médicale (INSERM), Service de psychopathologie de l'enfant et de l'adolescent, Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP)-Hôpital Robert Debré-Université Paris Diderot - Paris 7 (UPD7), Département de Psychiatrie, Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP)-Hôpital Albert Chenevier, RD is supported by a fellowship from the Fondation pour la Recherche Médicale and NC was the recipient of a fellowship from the INSERM. The authors thank the patients and their families who made this research possible, and the Centre d'Investigation Clinique, Hôpital Robert Debré, for technical assistance., and Betancur, Catalina
- Subjects
Male ,Obsessive-Compulsive Disorder ,MESH: Psychiatric Status Rating Scales ,Psychometrics ,[SDV.MHEP.PSM] Life Sciences [q-bio]/Human health and pathology/Psychiatrics and mental health ,0302 clinical medicine ,Surveys and Questionnaires ,MESH: Child ,lcsh:Psychiatry ,Prospective Studies ,Prospective cohort study ,Child ,Follow up studies ,Age Factors ,MESH: Genetic Heterogeneity ,MESH: Comparative Study ,MESH: Follow-Up Studies ,Exploratory factor analysis ,Psychiatry and Mental health ,Phenotype ,Female ,Psychology ,Research Article ,medicine.medical_specialty ,Adolescent ,lcsh:RC435-571 ,MESH: Factor Analysis, Statistical ,MESH: Phenotype ,MESH: Psych ,03 medical and health sciences ,Genetic Heterogeneity ,Obsessive compulsive ,medicine ,Humans ,Family ,Psychiatry ,MESH: Family ,Psychiatric Status Rating Scales ,MESH: Adolescent ,MESH: Age Factors ,MESH: Obsessive-Compulsive Disorder ,MESH: Humans ,Adult patients ,Genetic heterogeneity ,Reproducibility of Results ,Exploratory analysis ,MESH: Male ,MESH: Prospective Studies ,030227 psychiatry ,[SDV.MHEP.PSM]Life Sciences [q-bio]/Human health and pathology/Psychiatrics and mental health ,Factor Analysis, Statistical ,MESH: Female ,030217 neurology & neurosurgery ,Follow-Up Studies - Abstract
BackgroundRecent statistical approaches based on factor analysis of obsessive compulsive (OC) symptoms in adult patients have identified dimensions that seem more effective in symptom-based taxonomies and appear to be more stable over time. Although a phenotypic continuum from childhood to adulthood has been hypothesized, no factor analytic studies have been performed in juvenile patients, and the stability of OC dimensions in children and adolescents has not been assessed.MethodsThis study was designed to perform an exploratory factor analysis of OC symptoms in a sample of children and adolescents with OC disorder (OCD) and to investigate the course of factors over time (mean follow-up period: four years).ResultsWe report for the first time that four symptom dimensions, remarkably similar to those previously described in adults, underlined the heterogeneity of OC symptoms in children and adolescents. Moreover, after follow-up, the symptom dimensions identified remained essentially unmodified. The changes observed concerned the intensity of dimensions rather than shifts from one dimension to another.ConclusionThese findings reinforce the hypothesis of a phenotypic continuum of OC symptoms from childhood to adulthood. They also strengthen the interest for investigating the clinical, neurobiological and genetic heterogeneity of OCD using a dimension-based approach.
- Published
- 2006
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