1. Impact of cigarette smoking on the relationship between body mass index and coronary heart disease: a pooled analysis of 3264 stroke and 2706 CHD events in 378579 individuals in the Asia Pacific region
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L. S. Liu, Z. M. Chen, Z. Tang, Y. He, Atsushi Hozawa, J. Lee, T. Hashimoto, Matthew Knuiman, Annette J. Dobson, Graham G. Giles, B. F. Zhou, Michael Hobbs, Anthony Rodgers, Robyn J. Broadhurst, Hiroshi Maegawa, X. H. Yu, J. Zhou, D. F. Gu, Sohel Reza Choudhury, Stephen MacMahon, Y. H. Li, C. Q. Jiang, B. Zhou, Akihiko Nozaki, I. S. Kim, G. L. Shan, H. Y. Zhang, Mark Woodward, Noriaki Aoki, S. Ameratunga, Hiroshi Horibe, Z. Hong, Tim Welborn, H. Tanaka, X. H. Fang, Z. Z. Li, Z. S. Wu, M. S. Huang, W. H. Pan, Rodney Jackson, X. F. Duan, Il Suh, Kei Nakachi, S. C. Ho, Y. Kita, X. G. Wu, Y. Imai, M. Nakamura, Rachel R. Huxley, Xianghua Fang, S. C. Li, Piyamitr Sritara, Hirotsugu Ueshima, S. H. Jee, Mieko Kagaya, S. X. Yao, Z. L. Wu, J. L. Fuh, D. Heng, Hisatomi Arima, T. Ohkubo, K. Hughes, Shigeyuki Saitoh, Robyn Norton, M. Iida, Kiyomi Sakata, Yutaka Kiyohara, S. K. Chew, Akiko Tamakoshi, L. Q. Chen, Jean Woo, J. X. Xie, T. Yamada, Mary A. Luszcz, H. Christensen, Konrad Jamrozik, Hyeon Chang Kim, Gillian Whitlock, Akira Okayama, Tai Hing Lam, Yasuko Matsutani, Q. D. Yang, N. Kubo, Paul Norman, C. H. Yao, and Kazuaki Shimamoto
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Gerontology ,medicine.medical_specialty ,Asia ,medicine.medical_treatment ,Population ,Coronary Disease ,030204 cardiovascular system & hematology ,Overweight ,Body Mass Index ,Stroke - epidemiology - physiopathology ,Cohort Studies ,03 medical and health sciences ,0302 clinical medicine ,Risk Factors ,Weight loss ,Internal medicine ,Tobacco ,medicine ,Humans ,Coronary Disease - epidemiology - physiopathology ,030212 general & internal medicine ,cardiovascular diseases ,education ,Stroke ,Proportional Hazards Models ,2. Zero hunger ,education.field_of_study ,business.industry ,Smoking ,Weight change ,Public Health, Environmental and Occupational Health ,medicine.disease ,Confidence interval ,3. Good health ,Smoking cessation ,medicine.symptom ,business ,Body mass index ,Follow-Up Studies ,Research Article - Abstract
BACKGROUND: Elevated levels of body mass index (BMI) and smoking are well established lifestyle risk factors for coronary heart disease (CHD) and stroke. If these two risk factors have a synergistic relationship, rigorous lifestyle modification may contribute to greater reduction in cardiovascular burden than previously expected. METHODS: A pooled analysis of individual participant data from 38 cohorts, involving 378,579 participants. Hazards ratios (HRs) and 95% confidence intervals (CIs) for BMI by cigarette smoking status were estimated using Cox proportional hazard models. RESULTS: During a mean follow-up of 3.8 years, 2706 CHD and 3264 strokes were recorded. There was a log-linear, positive relationship of BMI with CHD and stroke in both smokers and non-smokers with evidence of a synergistic effect of smoking on the association between BMI and CHD only: HRs (95% CIs) associated with a 2 kg/m2 higher BMI were 1.13 (1.10-1.17) in current smokers and 1.09 (1.06-1.11) in non-smokers (p-value for interaction=0.04). CONCLUSION: Smoking amplifies the positive association between BMI and CHD but not stroke. If confirmed, these results suggest that effective strategies that target smoking cessation and weight loss are likely to have a greater impact than anticipated on reducing the burden of CHD., published_or_final_version
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