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Your search keyword '"Hebestreit, Helge"' showing total 4 results
Start Over Author "Hebestreit, Helge" Journal bmc pulmonary medicine
4 results on '"Hebestreit, Helge"'

2. Is sweat testing for cystic fibrosis feasible in patients with down syndrome?

Author

Ruf, Katharina, Demerath, Antonia, Hebestreit, Helge, and Kunzmann, Steffen

Subjects
Adult, Male, Adolescent, Cystic Fibrosis, Sweating, Thermoregulation, Young Adult, Sex Factors, Sweat secretion rate, Chlorides, Humans, ddc:610, Gender gap, Child, Sweat, lcsh:RC705-779, integumentary system, Age Factors, lcsh:Diseases of the respiratory system, Sweat osmolality, Non-responder, Case-Control Studies, Child, Preschool, Female, Down Syndrome, Research Article
Abstract

Background Recurrent airway infections are common in patients with Down’s syndrome (DS). Hence, ruling out Cystic Fibrosis (CF) in these patients is often required. In the past, the value of sweat testing – the gold standard to diagnose CF – has been questioned in DS as false positive results have been reported. However, these reports are based on measurements of sweat osmolality or sodium concentrations, not chloride concentrations. This study analyses sweat secretion rate and chloride concentration in sweat samples of patients with DS in comparison to healthy controls. Methods We assessed sweat samples in 16 patients with DS and 16 healthy controls regarding sweat secretion rate (SSR) and sweat chloride concentration. Results All measured chloride concentrations were within the normal range. The chloride concentrations were slightly, but not significantly lower in patients with DS (15,54 mmol/l (±4,47)) compared to healthy controls (18,31 mmol/l (±10,12)). While no gender gap in chloride concentration could be found, chloride concentration increased with age in both groups. Insufficient sweat was collected in 2 females with DS (12.5% of the study group) but not in an individual of the control group. A significant lower sweat secretion rate was found in the DS group (27,6 μl/30 min (± 12,18)) compared to the control group (42,7 μl/30 min (± 21,22)). In a sub-analysis, female patients produced significantly less sweat (20,8 ± 10,6 μl/30 min) than male patients with DS (36,4 ± 7,8 μl/30 min), which accounts for the difference between patients and controls. Furthermore, while the sweating secretion rate increased with age in the control group, it did not do so in the DS group. Once again this was due to female patients with DS, who did not show a significant increase of sweat secretion rate with age. Conclusions Sweat chloride concentrations were within the normal range in patients with DS and therefore seem to be a reliable tool for testing for CF in these patients. Interestingly, we found a reduced sweat secretion rate in the DS group. Whether the last one has a functional and clinical counterpart, possibly due to a disturbed thermoregulation in DS patients, requires further investigation.

Published
2018

4. Effects of a partially supervised conditioning programme in cystic fibrosis: an international multi-centre randomised controlled trial (ACTIVATE-CF): study protocol.

Author

Hebestreit, Helge, Lands, Larry C., Alarie, Nancy, Schaeff, Jonathan, Karila, Chantal, Orenstein, David M., Urquhart, Don S., Hulzebos, Erik H. J., Stein, Lothar, Schindler, Christian, Kriemler, Susi, Radtke, Thomas, the ACTIVATE-CF Study Working Group, and ACTIVATE-CF Study Working Group

Subjects
CYSTIC fibrosis, CYSTIC fibrosis treatment, PHYSICAL training & conditioning, EXERCISE physiology, PHYSICAL activity, QUALITY of life, HEALTH outcome assessment, PHYSICAL fitness
Abstract

Background: Physical activity (PA) and exercise have become an accepted and valued component of cystic fibrosis (CF) care. Regular PA and exercise can positively impact pulmonary function, improve physical fitness, and enhance health-related quality of life (HRQoL). However, motivating people to be more active is challenging. Supervised exercise programs are expensive and labour intensive, and adherence falls off significantly once supervision ends. Unsupervised or partially supervised programs are less costly and more flexible, but compliance can be more problematic. The primary objective of this study is to evaluate the effects of a partially supervised exercise intervention along with regular motivation on forced expiratory volume in 1 s (FEV1) at 6 months in a large international group of CF patients. Secondary endpoints include patient reported HRQoL, as well as levels of anxiety and depression, and control of blood sugar.Methods/design: It is planned that a total of 292 patients with CF 12 years and older with a FEV1 ≥ 35% predicted shall be randomised. Following baseline assessments (2 visits) patients are randomised into an intervention and a control group. Thereafter, they will be seen every 3 months for assessments in their centre for one year (4 follow-up visits). Along with individual counselling to increase vigorous PA by at least 3 h per week on each clinic visit, the intervention group documents daily PA and inactivity time and receives a step counter to record their progress within a web-based diary. They also receive monthly phone calls from the study staff during the first 6 months of the study. After 6 months, they continue with the step counter and web-based programme for a further 6 months. The control group receives standard care and keeps their PA level constant during the study period. Thereafter, they receive the intervention as well.Discussion: This is the first large, international multi-centre study to investigate the effects of a PA intervention in CF with motivational feedback on several health outcomes using modern technology. Should this relatively simple programme prove successful, it will be made available on a wider scale internationally.Trial Registration: ClinicalTrials.gov Identifier: NCT01744561 ; Registration date: December 6, 2012. [ABSTRACT FROM AUTHOR]

Published
2018
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