1. Automated computed tomographic scoring of lung disease in adults with primary ciliary dyskinesia
- Author
-
L. Bassinet, Marie-Pierre Revel, Bernard Maitre, Charlotte Martin, Trieu-Nghi Hoang-Thi, Thong Hua-Huy, Isabelle Honoré, Pierre-Régis Burgel, and Guillaume Chassagnon
- Subjects
Pulmonary and Respiratory Medicine ,Spirometry ,Adult ,Lung Diseases ,Male ,Vital capacity ,Vital Capacity ,Computed tomography ,Severity of Illness Index ,030218 nuclear medicine & medical imaging ,03 medical and health sciences ,FEV1/FVC ratio ,Young Adult ,0302 clinical medicine ,Primary ciliary dyskinesia ,Forced Expiratory Volume ,Image Interpretation, Computer-Assisted ,medicine ,Humans ,Retrospective Studies ,lcsh:RC705-779 ,Bronchiectasis ,Lung ,Kartagener syndrome ,medicine.diagnostic_test ,business.industry ,Mediastinum ,lcsh:Diseases of the respiratory system ,respiratory system ,Middle Aged ,medicine.disease ,respiratory tract diseases ,medicine.anatomical_structure ,030228 respiratory system ,Female ,Nuclear medicine ,business ,Tomography, X-Ray Computed ,Ciliary Motility Disorders ,Research Article - Abstract
Background The present study aimed to develop an automated computed tomography (CT) score based on the CT quantification of high-attenuating lung structures, in order to provide a quantitative assessment of lung structural abnormalities in patients with Primary Ciliary Dyskinesia (PCD). Methods Adult (≥18 years) PCD patients who underwent both chest CT and spirometry within a 6-month period were retrospectively included. Commercially available lung segmentation software was used to isolate the lungs from the mediastinum and chest wall and obtain histograms of lung density. CT-density scores were calculated using fixed and adapted thresholds based on various combinations of histogram characteristics, such as mean lung density (MLD), skewness, and standard deviation (SD). Additionally, visual scoring using the Bhalla score was performed by 2 independent radiologists. Correlations between CT scores, forced expiratory volume in 1 s (FEV1) and forced vital capacity (FVC) were evaluated. Results Sixty-two adult patients with PCD were included. Of all histogram characteristics, those showing good positive or negative correlations to both FEV1 and FVC were SD (R = − 0.63 and − 0.67; p
- Published
- 2018