1. Genetic risk, incident stroke, and the benefits of adhering to a healthy lifestyle: cohort study of 306 473 UK Biobank participants
- Author
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Rutten-Jacobs, Loes Ca, Larsson, Susanna C, Malik, Rainer, Rannikmäe, Kristiina, MEGASTROKE consortium, International Stroke Genetics Consortium, Sudlow, Cathie L, Dichgans, Martin, Markus, Hugh S, Traylor, Matthew, Rutten-Jacobs, Loes Ca [0000-0003-3223-885X], and Apollo - University of Cambridge Repository
- Subjects
Adult ,Male ,Multifactorial Inheritance ,Myocardial Infarction ,epidemiology [Cerebral Hemorrhage] ,Polymorphism, Single Nucleotide ,Risk Factors ,Humans ,Genetic Predisposition to Disease ,ddc:610 ,Healthy Lifestyle ,Prospective Studies ,genetics [Multifactorial Inheritance] ,Exercise ,Aged ,Cerebral Hemorrhage ,Incidence ,Research ,epidemiology [Subarachnoid Hemorrhage] ,Middle Aged ,Subarachnoid Hemorrhage ,epidemiology [Myocardial Infarction] ,United Kingdom ,Stroke ,genetics [Stroke] ,genetics [Polymorphism, Single Nucleotide] ,Patient Compliance ,Female ,physiology [Exercise] ,epidemiology [Stroke] - Abstract
Objective To evaluate the associations of a polygenic risk score and healthy lifestyle with incident stroke. Design Prospective population based cohort study. Setting UK Biobank Study, UK. Participants 306 473 men and women, aged 40-73 years, recruited between 2006 and 2010. Main outcome measure Hazard ratios for a first stroke, estimated using Cox regression. A polygenic risk score of 90 single nucleotide polymorphisms previously associated with stroke was constructed at P
- Published
- 2018
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