1. Real-time MRI guidance for intra-arterial drug delivery in a patient with a brain tumor: technical note.
- Author
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Zawadzki M, Walecki J, Kostkiewicz B, Kostyra K, Pearl MS, Solaiyappan M, Walczak P, and Janowski M
- Subjects
- Blood-Brain Barrier diagnostic imaging, Blood-Brain Barrier surgery, Brain Neoplasms pathology, Glioblastoma pathology, Humans, Imaging, Three-Dimensional, Infusions, Intra-Arterial methods, Magnetic Resonance Angiography methods, Magnetic Resonance Imaging, Interventional methods, Middle Aged, Antineoplastic Agents, Immunological administration & dosage, Bevacizumab administration & dosage, Brain Neoplasms drug therapy, Glioblastoma drug therapy
- Abstract
Patients with malignant brain tumors have a poor prognosis. The blood-brain barrier (BBB) is considered a primary obstacle in therapeutic drug delivery to the brain. Intra-arterial (IA) delivery of therapeutic agents following osmotic BBB opening has been attempted for years, but high variability has limited its widespread implementation. It has recently been shown in animal studies that MRI is superior to X-ray for guiding IA infusions, as it allows direct visualization of the brain parenchyma supplied by the catheter and facilitates predictable drug targeting. Moreover, PET imaging has shown that IA rather than intravenous delivery of bevacizumab results in accumulation in the brain, providing a strong rationale for using the IA route. We present a patient with recurrent butterfly glioblastoma enrolled in a first-in-man MRI-guided neurointervention for targeted IA drug delivery., Competing Interests: Competing interests: None declared., (© BMJ Publishing Group Limited 2019. No commercial re-use. See rights and permissions. Published by BMJ.)
- Published
- 2019
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