1. Prevalence of MRI lesions in men responding to a GP-led invitation for a prostate health check: a prospective cohort study
- Author
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Mieke Van Hemelrijck, Chris Brew-Graves, Neil McCartan, Louise Brown, Manuel Rodriguez-Justo, Aiman Haider, Alex Freeman, Mark Emberton, Kingshuk Pal, William Maynard, Aida Santaolalla, Nora Pashayan, Malcolm Mason, Tom Syer, Chris Parker, Caroline M Moore, Charlotte Bevan, Jayshireen Singh, Stuart Mackay-Thomas, Kate Walters, Mehul Mathukia, Charlotte Moss, David Sharpe, Kinnari Naik, Thomas Callender, Andrew Feber, Lee Berney, Anwar Padhani, Shonit Punwani, Hashim U Ahmed, Richard Kaplan, Teresa Marsden, Joanna Hadley, Steve Tuck, Saran Green, Ton Coolen, Elizabeth Isaac, Giorgio Brembilla, Douglas Kopcke, Francesco Giganti, Gerhardt Attard, Hina Pervez, Eric Aboagye, Elena Frangou, Fiona Gong, Louise C Brown, Aida Santa Olalla, Rosie Clow, Ged Corbett, Anna Wingate, Fatima Akbar, Suparna Thakali, Ashling Henderson, Dizem Tekin, Joey Clement, Harbit Sidhu, Teresita Beeston, Katerina Soteriou, Francesca Rawlins, Pirruntha Sivaharan, Savahnna Wolfe, Henry Tam, Heather Bholastewart, Sarp Keskin, Mariana Bertoncelli, Paul Boutros, Hayley Whitaker, Caroline Dive, Eytan Domany, Peter Parker, Andrew Prugia, Claire Chalmers-Watson, Alexander Gilkes, and Dr Hira
- Subjects
Neoplasms. Tumors. Oncology. Including cancer and carcinogens ,RC254-282 - Abstract
Objective In men with a raised prostate-specific antigen (PSA), MRI increases the detection of clinically significant cancer and reduces overdiagnosis, with fewer biopsies. MRI as a screening tool has not been assessed independently of PSA in a formal screening study. We report a systematic community-based assessment of the prevalence of prostate MRI lesions in an age-selected population.Methods and analysis Men aged 50–75 were identified from participating general practice (GP) practices and randomly selected for invitation to a screening MRI and PSA. Men with a positive MRI or a raised PSA density (≥0.12 ng/mL2) were recommended for standard National Health Service (NHS) prostate cancer assessment.Results Eight GP practices sent invitations to 2096 men. 457 men (22%) responded and 303 completed both screening tests. Older white men were most likely to respond to the invitation, with black men having 20% of the acceptance rate of white men.One in six men (48/303 men, 16%) had a positive screening MRI, and an additional 1 in 20 men (16/303, 5%) had a raised PSA density alone. After NHS assessment, 29 men (9.6%) were diagnosed with clinically significant cancer and 3 men (1%) with clinically insignificant cancer.Two in three men with a positive MRI, and more than half of men with clinically significant disease had a PSA
- Published
- 2023
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