1. Risk of pleural empyema in patients with schizophrenia: a nationwide propensity-matched cohort study in Taiwan
- Author
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Ting Chang Chang, Te Chun Shen, Yu-Jhen Huang, Te Chun Hsia, Chuen Ming Shih, Cheng-Li Lin, Fung-Chang Sung, Chia-Hung Chen, Chih Yen Tu, and Wu-Huei Hsu
- Subjects
Adult ,Male ,medicine.medical_specialty ,Taiwan ,propensity score matched ,03 medical and health sciences ,Young Adult ,0302 clinical medicine ,Risk Factors ,Internal medicine ,mental disorders ,medicine ,Humans ,030212 general & internal medicine ,pleural empyema ,Propensity Score ,Respiratory Medicine ,retrospective cohort study ,Empyema, Pleural ,Aged ,Proportional Hazards Models ,Retrospective Studies ,Proportional hazards model ,business.industry ,Incidence (epidemiology) ,Pleural empyema ,Research ,Incidence ,Retrospective cohort study ,General Medicine ,respiratory system ,Middle Aged ,medicine.disease ,Comorbidity ,030227 psychiatry ,respiratory tract diseases ,schizophrenia ,Schizophrenia ,Case-Control Studies ,Propensity score matching ,Cohort ,Female ,business - Abstract
ObjectiveThoracic infection and pneumonia are prevalent in patients with schizophrenia; however, it is unclear whether patients with schizophrenia are at an increased risk of developing pleural empyema.DesignA retrospective cohort study with propensity-matched cohorts with and without schizophrenia.SettingUsing the National Health Insurance Research Database of Taiwan.ParticipantsWe identified 55 888 patients with schizophrenia newly diagnosed in 2000–2011 and same number of individuals without schizophrenia as the comparison cohort, frequency matched by propensity scores estimated using age, sex, occupation, income, urbanisation, year of diagnosis and comorbidities.Primary outcome measuresWe assessed incident pleural empyema by the end of 2011 and used the Cox proportional hazards model to calculate the schizophrenia cohort to comparison cohort HR of pleural empyema.ResultsThe overall incidence of pleural empyema was 2.44-fold greater in the schizophrenia cohort than in the comparison cohort (4.39vs1.80 per 10 000 person-years), with an adjusted HR of 2.87(95% CI 2.14 to 3.84). Stratified analyses by age, sex, occupation, income, urbanisation and comorbidity revealed significant hazards for pleural empyema associated with schizophrenia in all subgroups.ConclusionsPatients with schizophrenia are at an increased risk of developing pleural empyema and require greater attention and appropriate support.
- Published
- 2018