1. Initiation of human regular U-500 insulin use is associated with improved glycemic control: a real-world US cohort study
- Author
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Robert C. Hood, Bradley H. Curtis, Richard M. Bergenstal, Iskandar Idris, Anne L. Peters, Steve Gelwicks, Elizabeth L. Eby, and Jeffrey A. Jackson
- Subjects
medicine.medical_specialty ,business.industry ,Endocrinology, Diabetes and Metabolism ,Glycemic Control ,Type 2 diabetes ,Hypoglycemia ,medicine.disease ,Bioinformatics ,Management ,chemistry.chemical_compound ,Insulin resistance ,chemistry ,Diabetes mellitus ,Internal medicine ,medicine ,Glycated hemoglobin ,Epidemiology/Health Services Research ,Insulin Resistance ,business ,Body mass index ,Cohort study ,Glycemic - Abstract
Aim Describe the characteristics of patients initiating human regular U-500 insulin (U-500R) and their subsequent glycemic control in a real-world setting. Methods US Humedica electronic health record system data (July 2007–September 2011) were used to identify patients with diabetes aged ≥18 years with ≥1 records for U-500R prescriptions, 6 months of preindex data, 12 months following first use of U-500R, and at least one glycated hemoglobin (HbA1c) value in both preindex and postindex periods. Paired t tests were used to measure the change in HbA1c from preindex to postindex periods (last or most recent values) and hypoglycemia. Results Among patients initiating U-500R (N=445), 96.9% had type 2 diabetes with mean age 57 years and mean body mass index 40.4 kg/m2. Postindex prescriptions were written for U-500R alone (47.0%, group A) and concomitant U-500R/U-100 insulins (53.0%, group B). Concomitant oral antihyperglycemic agents (AHAs) and non-insulin injectable AHAs were used by 43.4% and 14.6% of patients, respectively. Following initiation of U-500R, mean HbA1c improved 0.68% in all patients (p
- Published
- 2015
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