1. Antihypoxic and anti-ischemic properties of the North Caucasus flora plant extract
- Author
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Nataliya S Lyakhova, Denis S. Zolotych, Dmitry I. Pozdnyakov, Similya L Adzhiahmetova, Nadezhda M. Chervonnaya, Anastasiya E Pozdnyakova, and Kirill A Miroshnichenko
- Subjects
0106 biological sciences ,0301 basic medicine ,Necrosis ,Population ,Ischemia ,Plant Science ,Ribes ,01 natural sciences ,03 medical and health sciences ,Drug Discovery ,medicine ,education ,Sorbaria sorbifolia ,Gaillardia ,Pharmacology ,education.field_of_study ,biology ,Traditional medicine ,Hypoxia (medical) ,biology.organism_classification ,medicine.disease ,030104 developmental biology ,Complementary and alternative medicine ,Lysimachia punctata ,medicine.symptom ,010606 plant biology & botany - Abstract
Nowdays it is established that ischemic brain damage like ischemic stroke is one of the leading cause of death and disability in the population that assumes relevance development of anti-ischemic drugs. The work studied the anti-hypoxic and anti-ischemic effect of 7 plant extracts. Antihypoxic activity was assessed on models of hypobaric, hypercapnic, histotoxic, hematotoxic hypoxia. Anti-ischemic activity of test-extracts was studied on the focal cerebral ischemia model. Administration of Tagetes patula, Gaillardia pulchella, Sorbaria sorbifolia, Grossularia reclinata, Ribes nigrum, Rubus caesius and Lysimachia punctata extracts contributed to the necrosis zone reduction by 56.6% (p
- Published
- 2019