1. Peripheral blood lymphocyte subpopulations after splenectomy for trauma
- Author
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G, Chelazzi, G, Senaldi, G, Pinotti, C, Nicora, D, Rossi, and M, Mondelli
- Subjects
Adult ,Male ,B-Lymphocytes ,Adolescent ,T-Lymphocytes ,Antibodies, Monoclonal ,Fluorescent Antibody Technique ,Middle Aged ,Killer Cells, Natural ,Leukocyte Count ,Splenectomy ,Humans ,Lymphocytes ,Child ,Spleen ,Aged - Abstract
Absolute and percent numbers of peripheral blood lymphocyte (PBL) subpopulations were evaluated using monoclonal antibodies in 20 subjects splenectomised for trauma. A significant increase was observed in the absolute counts of total PBL, B, null and Leu 7+ cells and in the percent counts of null and Leu 7+ lymphocytes. The percent numbers of OKT11+, OKT4+ and OKT8+ lymphocytes were significantly reduced, but the OKT4+/OKT8+ ratio was not statistically different from normal controls. The increase in B and killer/natural killer cells may provide a compensatory mechanism responsible for surveillance against infections and tumors in splenectomised patients, despite the numerous humoral and cellular abnormalities they commonly display.
- Published
- 1987