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Your search keyword '"Rinaldi, E"' showing total 16 results
Start Over Author "Rinaldi, E" Journal bollettino della societa italiana di biologia sperimentale
16 results on '"Rinaldi, E"'

1. [Measurement of the erythrocyte galactokinase activity in patients with presenile and senile idiopathic cataract. Preliminary study]

Author

Simonelli F, Frunzio S, Rinaldi M, Balestrieri P, Alfonso Giovane, Cotticelli L, Rinaldi E, Simonelli, Francesca, Frunzio, S, Rinaldi, Michele, Balestrieri, P, Giovane, Alfonso, Cotticelli, L, and Rinaldi, E.

Subjects
Adult, Galactokinase, Erythrocytes, Age Factors, Galactose, Humans, Middle Aged, Cataract, Aged
Abstract

The activity of galactokinase in red blood cells, has been assayed in 17 patients with idiopathic senile and presenile cataract and in 12 age-matched subjects with perfectly transparent lenses. 3 of the idiopathic cataract patients (17.6%) showed low erythrocytes GK activity, while nobody in the control group showed reduced GK activity. Although preliminary, our results seem to support the possibility that a chronic disorder of galactose metabolism may be involved in the pathogenesis of the idiopathic senile and presenile cataract.

Published
1990

2. [Hydrogen peroxide in the aqueous humor and cataract formation in human diabetes]

Author

SIMONELLI, Francesca, PENSA M, TERAMO P, AMICONE A, RUSSO P, PERILLO F, COTTICELLI L, RINALDI E. RELATED ARTICLES, LINKS, Simonelli, Francesca, Pensa, M, Teramo, P, Amicone, A, Russo, P, Perillo, F, Cotticelli, L, RINALDI E., RELATED ARTICLES, and Links

Subjects
Aqueous Humor, Diabetes Complications, Oxygen, Diabetic Retinopathy, genetic structures, Free Radicals, Diabetes Mellitus, Humans, sense organs, Hydrogen Peroxide, Lipid Peroxidation, eye diseases, Cataract
Abstract

Hydrogen peroxide in the aqueous humor was measured in cataractous eyes from normal subjects and in cataractous eyes from diabetic subjects. The level of H2O2 in the aqueous humor was significantly higher in diabetes than in the idiopathic forms. It is likely that in the eye, impaired enzymic defenses lead to the accumulation of reactive species of O2, such as H2O2, which induces lipid peroxidation. This mechanism may be involved, as a direct consequence of retinal damage, in the pathogenesis of cataract in diabetes.

Published
1990

3. [Role of the non-enzymatic glycosylation of protein in the formation of human cataracts]

Author

SIMONELLI, Francesca, PENSA M, RINALDI E. RELATED ARTICLES, LINKS, Simonelli, Francesca, Pensa, M, RINALDI E., RELATED ARTICLES, and Links

Subjects
Adult, Aged, 80 and over, Male, Aging, Glycosylation, genetic structures, Lysine, Middle Aged, eye diseases, Cataract, Diabetes Mellitus, Type 2, Humans, Female, sense organs, Eye Proteins, Schiff Bases, Aged
Abstract

We have measured the free epsilon amino groups in soluble and insoluble proteins of clear human lenses and diabetic and non-diabetic senile cataractous lenses. The free epsilon amino groups content of soluble and insoluble proteins was significantly lower in diabetic cataracts than in clear lenses and non diabetic senile cataracts. Our results seem to demonstrate that non-enzymatic glycosylation of lens protein could play a role in the pathogenesis of cataract in diabetes.

Published
1989

4. [Possible role of altered levels of plasma docosahexaenoic acid in the pathogenesis of retinitis pigmentosa. Preliminary results].

Author

Simonelli F, Milone A, Iura A, Picardi C, La Banca AM, Cotticelli L, and Rinaldi E

Subjects
Fatty Acids, Unsaturated metabolism, Genes, Dominant, Genes, Recessive, Humans, Membrane Lipids metabolism, Photoreceptor Cells metabolism, Retinitis Pigmentosa genetics, Docosahexaenoic Acids blood, Retinitis Pigmentosa blood
Abstract

Plasma samples obtained from Retinitis Pigmentosa (R.P.) patients and controls were assayed for docosahexaenoic acid (DXA), the major fatty acid in photoreceptor cells, in order to evaluate the possibility that abnormalities in PUFA metabolism could be involved in R.P. pathogenesis. Our preliminary results show levels of plasma DXA in dominantly inherited R.P. lower than in the recessive forms and controls.

Published
1990

5. [Lipid peroxidation and cataract formation in experimental diabetes].

Author

Simonelli F, Cotticelli L, Pensa M, Teramo P, Acampora A, and Rinaldi E

Subjects
Animals, Diabetes Mellitus, Experimental complications, Diabetes Mellitus, Experimental physiopathology, Lens, Crystalline metabolism, Malonates, Malondialdehyde metabolism, Rats, Cataract etiology, Diabetes Mellitus, Experimental metabolism, Lens, Crystalline analysis, Lipid Peroxidation physiology, Malondialdehyde analysis
Abstract

To investigate the role of lipid peroxidation in diabetic cataractogenesis, malondialdehyde, a breakdown product of lipid peroxidation, was measured in lenses with incipient opacities and in retinas from diabetic rats and in clear lenses and in retinas from normal rats. The malondialdehyde mean values obtained in the transparent and cataractous lenses showed non-significant differences, while non-diabetic rat retinas had a significantly lower mean level of malondialdehyde compared with diabetic rat retinas (p less than 0.01). This indicates that, in streptozotocin-induced diabetic rats, lipid peroxidation is apparently not involved in the development of cataract, but it is quite probably involved in retinal damage. The retina, richer in polyunsaturated fatty acids than other ocular structures, is the elective site of lipid peroxidation and from this membrane peroxidation products might probably diffuse and damage other ocular tissues.

Published
1989

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