1. Immunohistochemical reactivity of anti-LAV p18 monoclonal antibody in lymph nodes from PGL and AIDS patients.
- Author
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Parravicini CL, Vago L, Costanzi GC, Gluckman JC, Klatzmann D, Berti E, Barre-Sinoussi F, Chermann JC, Lazzarin A, and Moroni M
- Subjects
- Antibodies, Viral analysis, Antibodies, Viral immunology, Biopsy, Histocytochemistry, Humans, Acquired Immunodeficiency Syndrome immunology, Antibodies, Monoclonal immunology, Deltaretrovirus immunology, Lymph Nodes immunology, Lymphatic Diseases immunology
- Abstract
This study deals with the immunohistochemistry of a monoclonal antibody (Mab) raised against the p18 protein of the LAV virus in lymphnodes from 20 cases of persistent generalized lymphoadenopathy (PGL) (2) and 6 of acquired immunodeficiency syndrome (AIDS) (3). In all the PGL cases that have been studied, we observed a very important disruption of the follicular dendritic cell's (FDC) framework in the germinal centers which is associated with the presence of an increased number of Leu2a+ lymphocytes inside the germinal centers. This observation is consistent with the main morphological feature of the lymphnodes in the PGL syndrome which is mainly characterized by lesions of FD cells.
- Published
- 1985