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3. Supplementation of children with type 1 diabetes with milk or pharmacological calcium for improving bone health - a randomized controlled trial

Author

Veena Ekbote, Zulf Mughal, Shashi Chiplonkar, Vaman Khadilkar, Anuradha Khadilkar, Sonal Palande, Nikhil Lohiya, and Raja Padidela

Subjects
Type 1 diabetes, medicine.medical_specialty, business.industry, chemistry.chemical_element, General Medicine, Calcium, medicine.disease, Bone health, law.invention, chemistry, Randomized controlled trial, law, Internal medicine, medicine, business
Published
2019
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4. Assessment of bone density by DXA in poorly controlled children with β-Thalassemia: Correction for hepatic iron - overloadby manual analysis

Author

Raja Padidela, Sujata Chauthmal, Veena Ekbote, Shachi Khadilkar, Zulf Mughal, Anuradha Khadilkar, and Nicola Crabtree

Subjects
musculoskeletal diseases, 0301 basic medicine, medicine.medical_specialty, Iron Overload, Bone density, Anemia, Endocrinology, Diabetes and Metabolism, Thalassemia, Urology, 030209 endocrinology & metabolism, Gastroenterology, Young Adult, 03 medical and health sciences, Absorptiometry, Photon, 0302 clinical medicine, Bone Density, Internal medicine, medicine, Humans, Radiology, Nuclear Medicine and imaging, Orthopedics and Sports Medicine, Chelation therapy, Hepatic iron, Child, Lumbar Vertebrae, business.industry, beta-Thalassemia, Beta thalassemia, General Medicine, medicine.disease, Liver, Lumbar spine, 030101 anatomy & morphology, Hemoglobin, business
Abstract

Introduction Beta thalassemia major (BTM) is characterized by anemia and iron overload, especially with inadequate chelation therapy. Dual energy x-ray absorptiometry software (DXA) may misanalyse bone measurements due to iron deposition in organs such as the liver. Our objective was to study difference between the posterior-anterior spine measurements of bone mineral content (BMC), area (BA) and density (BMD) in poorly chelated beta thalassemia patients with and without inclusion of the liver in the DXA analysis. Methods We studied haemoglobin and serum ferritin concentrations in 208 patients with BTM (children n=177, young adults n=31). PA Spine measurements BMC, BA and areal BMD were performed using a GE iDXA. Using the tissue point typing feature (EnCore software, version 16), analysis was carried out including and excluding (manually) the iron overloaded liver. Machine generated Z-scores of L1-L4 BMD were used for analysis. Results The mean age of the study group was 12.9 ± 5.4yrs. Mean hemoglobin and serum ferritin concentrations were 8.0 ±1.7 g/dl and 2256.9 ±1978.0 ng/ml respectively. The mean BMC, BA and aBMD at the lumbar spine were 23.2 ± 11.4 g, 29.9 ± 8.5 cm2 and 0.736 ± 0.173 g.cm2 respectively with inclusion of liver that is standard machine analysis. After the liver was excluded from the analysis, the mean BMC, BA and aBMD were 23.9 ± 11.6 g, 30.0 ± 8.6 cm2 and 0.757 ±0.173 g/cm2 respectively and the BMC and aBMD were significantly greater (p Conclusion In poorly chelated patients with thalassemia, inclusion of the iron-overloaded liver in the tissue analysis may exaggerate the deficit in bone parameters. Iron overloaded tissues need to be manually excluded during analysis of the PA spine.

Published
2019
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8. Gender specific paediatric reference data for muscle function parameters assessed using jumping mechanography

Author

Smruti Vispute, Sonal Palande, Vaman Khadilkar, Rainer Rawer, Veena Ekbote, Zulf Mughal, Raja Padidela, Anuradha Khadilkar, and Shashi Chiplonkar

Subjects
medicine.medical_specialty, Jumping, Physical medicine and rehabilitation, Reference data (financial markets), medicine, Parameter, General Medicine, medicine.disease_cause, Mathematics
Published
2019
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9. Paradoxical response of serum parathyroid hormone concentration in response to vitamin D and calcium supplementation in undernourished Indian children

Author

Vivek Patwardhan, Raja Padidela, Vaman Khadilkar, Neha Kajale, Veena Ekbote, Zulf Mughal, Rubina Mandlik, and Anuradha Khadilkar

Subjects
medicine.medical_specialty, Calcium supplementation, Endocrinology, business.industry, Internal medicine, Vitamin D and neurology, Medicine, Parathyroid hormone, Paradoxical reaction, General Medicine, business
Published
2017
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10. Effects of vitamin D with calcium supplementation or zinc supplementation on the incidence of infections in school children: a randomized controlled trial

Author

Shashi Chiplonkar, Raja Padidela, Vivek Patwardhan, Veena Ekbote, Anuradha Khadilkar, Zulf Mughal, Vaman Khadilkar, and Rubina Mandlik

Subjects
medicine.medical_specialty, business.industry, Incidence (epidemiology), chemistry.chemical_element, General Medicine, Zinc, Gastroenterology, law.invention, Calcium supplementation, Randomized controlled trial, chemistry, law, Internal medicine, Vitamin D and neurology, Medicine, business
Published
2017
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11. Bone health status in Indian children with type 1 diabetes as assessed by peripheral quantitative computer tomography (pQCT)

Author

Neha Kajale, Raja Padidela, Shriram Narwade, Shashi Chiplonkar, Rubina Mandlik, Vaman Khadilkar, Veena Ekbote, Anuradha Khadilkar, Zulf Mughal, Shital Bhor, and Jwala Pawar

Subjects
Type 1 diabetes, medicine.medical_specialty, business.industry, medicine, General Medicine, Tomography, Radiology, medicine.disease, business, Bone health, Peripheral
Published
2017
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14. Validation of questionnaire for measurement of sunlight exposure in children from Pune, India

Author

Varsha Deshpande, Anjali Jaiswal, Smruti Vispute, Varsha Vartak, Utkarshini Kirtikar, Sonal Palande, Veena Ekbote, Raja Padidela, Vaman Khadilkar, Vivek Patwardhan, Anuradha Khadilkar, Rubina Mandlik, Zulf Mughal, Natasha Michael, Pranati Deshpande, Shashi Chiplonkar, Neha Kajale, and Dipali Ladkat

Subjects
Sunlight, business.industry, Environmental health, Medicine, General Medicine, business
Published
2017
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17. Association of vitamin D concentrations with 7-Dehydrocholesterol Reductase in school children in a sun-rich, semi-rural setting in Western Maharashtra, India

Author

Anuradha Khadilkar, Rubina Mandlik, Shashi Chiplonkar, Neha Kajale, Veena Ekbote, Vaman Khadilkar, Vivek Patwardhan, and Zulf Mughal

Subjects
7-Dehydrocholesterol reductase, business.industry, Environmental health, Vitamin D and neurology, Rural setting, Medicine, General Medicine, Ancient history, business
Published
2015
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