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1. OBITUARY- Riccardo Saccardi (20th April 1956–19th February 2024)

Author

Bacigalupo, Andrea, primary, Bonifazi, Francesca, additional, Ciceri, Fabio, additional, Gluckman, Eliane, additional, Greco, Raffaella, additional, Nozzoli, Chiara, additional, Lombardini, Letizia, additional, Martino, Massimo, additional, Rambaldi, Alessandro, additional, Rocha, Vanderson, additional, Ruggeri, Annalisa, additional, Snowden, John, additional, and Sureda, Anna, additional

Published
2024
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2. The European Society for Blood and Marrow Transplantation (EBMT) Consensus Guidelines for the Detection and Treatment of Donor-specific Anti-HLA Antibodies (DSA) in Haploidentical Hematopoietic Cell Transplantation

Author

Ciurea, Stefan O, Cao, Kai, Fernandez-Vina, Marcelo, Kongtim, Piyanuch, Malki, Monzr Al, Fuchs, Ephraim, Luznik, Leo, Huang, Xiao-Jun, Ciceri, Fabio, Locatelli, Franco, Aversa, Franco, Castagna, Luca, Bacigalupo, Andrea, Martelli, Massimo, Blaise, Didier, Handgretinger, Rupert, Roy, Denis-Claude, O’Donnell, Paul, Bashey, Asad, Lazarus, Hillard M, Ballen, Karen, Savani, Bipin N, Mohty, Mohamad, and Nagler, Arnon

Subjects
Transplantation, Regenerative Medicine, Stem Cell Research, Organ Transplantation, Development of treatments and therapeutic interventions, 5.4 Surgery, Inflammatory and immune system, Bone Marrow Transplantation, Graft Rejection, HLA Antigens, Hematopoietic Stem Cell Transplantation, Humans, Isoantibodies, Tissue Donors, Transplantation, Haploidentical, Treatment Outcome, Clinical Sciences, Oncology and Carcinogenesis, Immunology
Abstract

Haploidentical donors are now increasingly considered for transplantation in the absence of HLA-matched donors or when an urgent transplant is needed. Donor-specific anti-HLA antibodies (DSA) have been recently recognized as an important barrier against successful engraftment of donor cells, which can affect transplant survival. DSA appear more prevalent in this type of transplant due to higher likelihood of alloimmunization of multiparous females against offspring's HLA antigens, and the degree of mismatch. Here we summarize the evidence for the role of DSA in the development of primary graft failure in haploidentical transplantation and provide consensus recommendations from the European Society for Blood and Marrow Transplant Group on testing, monitoring, and treatment of patients with DSA receiving haploidentical hematopoietic progenitor cell transplantation.

Published
2018

3. Harmonizing definitions for hematopoietic recovery, graft rejection, graft failure, poor graft function, and donor chimerism in allogeneic hematopoietic cell transplantation: a report on behalf of the EBMT, ASTCT, CIBMTR, and APBMT

Author

Sureda, Anna, primary, Carpenter, Paul A., additional, Bacigalupo, Andrea, additional, Bhatt, Vijaya Raj, additional, de la Fuente, Josu, additional, Ho, Aloysius, additional, Kean, Leslie, additional, Lee, Jong Wook, additional, Sánchez-Ortega, Isabel, additional, Savani, Bipin N., additional, Schetelig, Johannes, additional, Stadtmauer, Edward A., additional, Takahashi, Yoshiyuki, additional, Atsuta, Yoshiko, additional, Koreth, John, additional, Kröger, Nicolaus, additional, Ljungman, Per, additional, Okamoto, Shinichiro, additional, Popat, Uday, additional, Soiffer, Robert, additional, Stefanski, Heather E., additional, and Kharfan-Dabaja, Mohamed A., additional

Published
2024
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4. Post-transplant cyclophosphamide with Sirolimus or Cyclosporine for GvHD prophylaxis in matched related and unrelated transplantation: a two-center analysis on 213 consecutive patients

Author

Piemontese, Simona, primary, Lupo Stanghellini, Maria Teresa, additional, Sora, Federica, additional, Sica, Simona, additional, Peccatori, Jacopo, additional, Marcatti, Magda, additional, Metafuni, Elisabetta, additional, Giammarco, Sabrina, additional, Greco, Raffaella, additional, Bruno, Alessandro, additional, Ciceri, Fabio, additional, Bacigalupo, Andrea, additional, and Chiusolo, Patrizia, additional

Published
2024
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6. Impact of second-degree related donor on the outcomes of T cell-replete haploidentical transplantation with post-transplant cyclophosphamide

Author

Mariotti, Jacopo, primary, Raiola, Anna Maria, additional, Evangelista, Andrea, additional, Harbi, Samia, additional, Patriarca, Francesca, additional, Carella, Michele Angelo, additional, Martino, Massimo, additional, Risitano, Antonio, additional, Busca, Alessandro, additional, Giaccone, Luisa, additional, Brunello, Lucia, additional, Merla, Emanuela, additional, Savino, Lucia, additional, Loteta, Barbara, additional, Console, Giuseppe, additional, Fanin, Renato, additional, Sperotto, Alessandra, additional, Marano, Luana, additional, Marotta, Serena, additional, Frieri, Camilla, additional, Sica, Simona, additional, Chiusolo, Patrizia, additional, Chabannon, Christian, additional, Furst, Sabine, additional, Santoro, Armando, additional, Bacigalupo, Andrea, additional, Bruno, Benedetto, additional, Blaise, Didier, additional, Mavilio, Domenico, additional, Bramanti, Stefania, additional, Devillier, Raynier, additional, Angelucci, Emanuele, additional, and Castagna, Luca, additional

Published
2022
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7. Autologous stem cell transplantation as bridging therapy followed by CD19 CAR-T cells in relapsed-refractory large B cell lymphoma

Author

Galli, Eugenio, primary, Sorà, Federica, additional, Hohaus, Stefan, additional, Bellesi, Silvia, additional, Autore, Francesco, additional, Metafuni, Elisabetta, additional, Innocenti, Idanna, additional, Marra, John, additional, Fresa, Alberto, additional, Limongiello, Maria Assunta, additional, Giammarco, Sabrina, additional, Leccisotti, Lucia, additional, Guarneri, Andrea, additional, Chiusolo, Patrizia, additional, Laurenti, Luca, additional, Teofili, Luciana, additional, Piccirillo, Nicola, additional, Bacigalupo, Andrea, additional, and Sica, Simona, additional

Published
2022
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8. Triple post transplant cyclophosphamide (PTCY) based GVHD prophylaxis: HLA matched versus HLA haploidentical transplants

Author

Galli, Eugenio, primary, Metafuni, Elisabetta, additional, Giammarco, Sabrina, additional, Limongiello, Maria Assunta, additional, Innocenti, Idanna, additional, Autore, Francesco, additional, Laurenti, Luca, additional, Sorà, Federica, additional, Chiusolo, Patrizia, additional, Teofili, Luciana, additional, Bacigalupo, Andrea, additional, and Sica, Simona, additional

Published
2022
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9. Second haploidentical stem cell transplantation for primary graft failure

Author

Giammarco, Sabrina, primary, Raiola, Anna Maria, additional, Di Grazia, Carmen, additional, Bregante, Stefania, additional, Gualandi, Francesca, additional, Varaldo, Riccardo, additional, Chiusolo, Patrizia, additional, Sora, Federica, additional, Sica, Simona, additional, Laurenti, Luca, additional, Metafuni, Elisabetta, additional, Innocenti, Idanna, additional, Autore, Francesco, additional, Murgia, Barbara, additional, Bacigalupo, Andrea, additional, and Angelucci, Emanuele, additional

Published
2020
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10. Haploidentical hematopoietic stem cell transplantation in aplastic anemia: a systematic review and meta-analysis of clinical outcome on behalf of the severe aplastic anemia working party of the European group for blood and marrow transplantation (SAAWP of EBMT)

Author

ElGohary, Ghada, primary, El Fakih, Riad, additional, de Latour, Regis, additional, Risitano, Antonio, additional, Marsh, Judith, additional, Schrezenmeier, Hubert, additional, Gluckman, Eliane, additional, Höchsmann, Britta, additional, Pierri, Filomena, additional, Halkes, Constantijn, additional, Alzahrani, Hazzaa, additional, De la Fuente, Josu, additional, Cesaro, Simone, additional, Alahmari, Ali, additional, Ahmed, Syed Osman, additional, Passweg, Jakob, additional, Dufour, Carlo, additional, Bacigalupo, Andrea, additional, and Aljurf, Mahmoud, additional

Published
2020
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11. Treatment of steroid resistant acute graft versus host disease with an anti-CD26 monoclonal antibody—Begelomab

Author

Bacigalupo, Andrea, primary, Angelucci, Emanuele, additional, Raiola, Anna Maria, additional, Varaldo, Riccardo, additional, Di Grazia, Carmen, additional, Gualandi, Francesca, additional, Benedetti, Edoardo, additional, Risitano, Antonio, additional, Musso, Maurizio, additional, Zallio, Francesco, additional, Ciceri, Fabio, additional, Chiusolo, Patrizia, additional, Sica, Simona, additional, Rambaldi, Alessandro, additional, Bonifazi, Francesca, additional, Parma, Matteo, additional, Martino, Massimo, additional, Onida, Francesco, additional, Iori, Anna Paola, additional, Selleri, Carmine, additional, Borghero, Carlo, additional, Bertaina, Alice, additional, Prezioso, Lucia, additional, Algeri, Mattia, additional, and Locatelli, Franco, additional

Published
2020
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12. Rabbit ATG/ATLG in preventing graft-versus-host disease after allogeneic stem cell transplantation: consensus-based recommendations by an international expert panel

Author

Bonifazi, Francesca, primary, Rubio, Marie-Thérèse, additional, Bacigalupo, Andrea, additional, Boelens, Jaap Jan, additional, Finke, Jürgen, additional, Greinix, Hildegard, additional, Mohty, Mohamad, additional, Nagler, Arnon, additional, Passweg, Jakob, additional, Rambaldi, Alessandro, additional, Socie, Gérard, additional, Solano, Carlos, additional, Walker, Irwin, additional, Barosi, Giovanni, additional, and Kröger, Nicolaus, additional

Published
2020
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14. Graft versus host disease in unmanipulated haploidentical marrow transplantation with a modified post-transplant cyclophosphamide (PT-CY) regimen: an update on 425 patients

Author

Bacigalupo, Andrea, primary, Maria Raiola, Anna, additional, Dominietto, Alida, additional, Di Grazia, Carmen, additional, Gualandi, Francesca, additional, Lint, Maria Teresa Van, additional, Chiusolo, Patrizia, additional, Laurenti, Luca, additional, Sora, Federica, additional, Giammarco, Sabrina, additional, and Angelucci, Emanuele, additional

Published
2019
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15. Hematopoietic stem cell transplantation with unrelated cord blood or haploidentical donor grafts in adult patients with secondary acute myeloid leukemia, a comparative study from Eurocord and the ALWP EBMT

Author

Ruggeri, Annalisa, primary, Labopin, Myriam, additional, Savani, Bipin, additional, Paviglianiti, Annalisa, additional, Blaise, Didier, additional, Volt, Fernanda, additional, Ciceri, Fabio, additional, Bacigalupo, Andrea, additional, Tischer, Johanna, additional, Chevallier, Patrice, additional, Koc, Yener, additional, Cornelissen, Jan J., additional, Ehninger, Gerard, additional, Sanz, Guillermo, additional, Deconinck, Erick, additional, Rocha, Vanderson, additional, Baron, Frederic, additional, Mohty, Mohamad, additional, Gluckman, Eliane, additional, and Nagler, Arnon, additional

Published
2019
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16. The European Society for Blood and Marrow Transplantation (EBMT) consensus recommendations for donor selection in haploidentical hematopoietic cell transplantation

Author

Ciurea, Stefan O., primary, Al Malki, Monzr M., additional, Kongtim, Piyanuch, additional, Fuchs, Ephraim J., additional, Luznik, Leo, additional, Huang, Xiao-Jun, additional, Ciceri, Fabio, additional, Locatelli, Franco, additional, Aversa, Franco, additional, Castagna, Luca, additional, Bacigalupo, Andrea, additional, Martelli, Massimo, additional, Blaise, Didier, additional, Ben Soussan, Patrick, additional, Arnault, Yolande, additional, Handgretinger, Rupert, additional, Roy, Denis-Claude, additional, O’Donnell, Paul V., additional, Bashey, Asad, additional, Solomon, Scott, additional, Romee, Rizwan, additional, Gayoso, Jorge, additional, Lazarus, Hillard M., additional, Ballen, Karen, additional, Savani, Bipin N., additional, Mohty, Mohamad, additional, and Nagler, Arnon, additional

Published
2019
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17. Special issues related to the diagnosis and management of acquired aplastic anemia in countries with restricted resources, a report on behalf of the Eastern Mediterranean blood and marrow transplantation (EMBMT) group and severe aplastic anemia working party of the European Society for blood and marrow transplantation (SAAWP of EBMT)

Author

Iftikhar, Raheel, Ahmad, Parvez, de Latour, Regis, Dufour, Carlo, Risitano, Antonio, Chaudhri, Naeem, Bazarbachi, Ali, De La Fuente, Josu, Höchsmann, Britta, Osman Ahmed, Syed, Gergis, Usama, Elhaddad, Alaa, Halkes, Constantijn, Albeirouti, Bassim, Alotaibi, Sultan, Kulasekararaj, Austin, Alzahrani, Hazzaa, Ben Othman, Tarek, Cesaro, Simone, Alahmari, Ali, Rihani, Rawad, Alshemmari, Salem, Hamidieh, Amir Ali, Bekadja, Mohamed-Amine, Passweg, Jakob, Al-Khabori, Murtadha, Rasheed, Walid, Bacigalupo, Andrea, Chaudhry, Qamar-Un-Nisa, Ljungman, Per, Marsh, Judith, El Fakih, Riad, and Aljurf, Mahmoud

Abstract

Aplastic anemia is a relatively rare but potentially fatal disorder, with a reported higher incidence in developing countries in comparison to the West. There are significant variations in epidemiological as well as etiological factors of bone marrow failure syndromes in the developing countries in comparison to the developed world. Furthermore, the management of bone marrow failure syndromes in resource constraint settings has significant challenges including delayed diagnosis and referral, limited accessibility to healthcare facilities, treatment modalities as well as limitations related to patients who require allogeneic stem cell transplantation. Here we will provide a review of the available evidence related to specific issues of aplastic anemia in the developing countries and we summarize suggested recommendations from the Eastern Mediterranean blood and bone marrow transplantation (EMBMT) group and the severe aplastic anemia working party of the European Society of blood and marrow transplantation (SAAWP of EBMT) related to the diagnosis and therapeutic options in countries with restricted resources.

Published
2021
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18. Second haploidentical stem cell transplantation for primary graft failure

Author

Giammarco, Sabrina, Raiola, Anna Maria, Di Grazia, Carmen, Bregante, Stefania, Gualandi, Francesca, Varaldo, Riccardo, Chiusolo, Patrizia, Sora, Federica, Sica, Simona, Laurenti, Luca, Metafuni, Elisabetta, Innocenti, Idanna, Autore, Francesco, Murgia, Barbara, Bacigalupo, Andrea, and Angelucci, Emanuele

Abstract

We report the outcome of 19 patients who experienced primary graft failure (PrGF) after a haploidentical (HAPLO), unmanipulated bone marrow transplant. The median age of patients was 52 years; the conditioning regimen of the first HAPLO transplant was either full dose total body irradiation (TBI) or fludarabine, busulfan, and thiotepa (TBF); PTCY was given to all patients together with cyclosporine and mycophenolate. All 19 patients with PrGF received a second HAPLO graft, at a median interval of 42 days (34–82) after HSCT, using the Baltimore protocol and G-CSF mobilized PB from the same (n= 13) or another HAPLO family donor (n= 6). GvHD prophylaxis was again PTCY-based; 14/19 patients had trilineage recovery (74%) and 1-year survival was 66%. Engraftment at second HAPLO was seen in 7/8 patient with, and in 5/7 patients without donor-specific antibodies (DSA). In a multivariate logistic regression analysis on the original group of 503 patients, there was a trend for a reduced dose of busulfan, to increase the risk of PrGF (p= 0.1). In conclusion, patients with PrGF following a HAPLO transplant, can be rescued with a second early HAPLO transplant, using the same or a different donor.

Published
2021
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19. Correction: Harmonizing definitions for hematopoietic recovery, graft rejection, graft failure, poor graft function, and donor chimerism in allogeneic hematopoietic cell transplantation: a report on behalf of the EBMT, ASTCT, CIBMTR, and APBMT

Author

Sureda, Anna, Carpenter, Paul A., Bacigalupo, Andrea, Bhatt, Vijaya Raj, de la Fuente, Josu, Ho, Aloysius, Kean, Leslie, Lee, Jong Wook, Sánchez-Ortega, Isabel, Savani, Bipin N., Schetelig, Johannes, Stadtmauer, Edward A., Takahashi, Yoshiyuki, Atsuta, Yoshiko, Koreth, John, Kröger, Nicolaus, Ljungman, Per, Okamoto, Shinichiro, Popat, Uday, Soiffer, Robert, Stefanski, Heather E., and Kharfan-Dabaja, Mohamed A.

Published
2024
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20. Correction: The European Society for Blood and Marrow Transplantation (EBMT) Consensus Guidelines for the Detection and Treatment of Donor-specific Anti-HLA Antibodies (DSA) in Haploidentical Hematopoietic Cell Transplantation

Author

Ciurea, Stefan O., primary, Cao, Kai, additional, Fernandez-Vina, Marcelo, additional, Kongtim, Piyanuch, additional, Malki, Monzr Al, additional, Fuchs, Ephraim, additional, Luznik, Leo, additional, Huang, Xiao-Jun, additional, Ciceri, Fabio, additional, Locatelli, Franco, additional, Aversa, Franco, additional, Castagna, Luca, additional, Bacigalupo, Andrea, additional, Martelli, Massimo, additional, Blaise, Didier, additional, Handgretinger, Rupert, additional, Roy, Denis-Claude, additional, O’Donnell, Paul, additional, Bashey, Asad, additional, Lazarus, Hillard M., additional, Ballen, Karen, additional, Savani, Bipin N., additional, Mohty, Mohamad, additional, and Nagler, Arnon, additional

Published
2018
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22. The European Society for Blood and Marrow Transplantation (EBMT) consensus recommendations for donor selection in haploidentical hematopoietic cell transplantation

Author

Ciurea, Stefan O., Al Malki, Monzr M., Kongtim, Piyanuch, Fuchs, Ephraim J., Luznik, Leo, Huang, Xiao-Jun, Ciceri, Fabio, Locatelli, Franco, Aversa, Franco, Castagna, Luca, Bacigalupo, Andrea, Martelli, Massimo, Blaise, Didier, Ben Soussan, Patrick, Arnault, Yolande, Handgretinger, Rupert, Roy, Denis-Claude, O’Donnell, Paul V., Bashey, Asad, Solomon, Scott, Romee, Rizwan, Gayoso, Jorge, Lazarus, Hillard M., Ballen, Karen, Savani, Bipin N., Mohty, Mohamad, and Nagler, Arnon

Abstract

The number of HLA-haploidentical hematopoietic cell transplants continues to increase worldwide due to recent improvements in outcomes, allowing more patients with hematological malignancies and non-malignant disorders to benefit from this procedure and have a chance to cure their disease. Despite these encouraging results, questions remain as multiple donors are usually available for transplantation, and choosing the best HLA-haploidentical donor for transplantation remains a challenge. Several approaches to haploidentical transplantation have been developed over time and, based on the graft received, can be grouped as follows: T-cell depleted haploidentical transplants, either complete or partial, or with T-cell replete grafts, performed with post-transplant cyclophosphamide-based graft-versus-host disease (GVHD) prophylaxis, or G-CSF-primed bone marrow graft and enhanced GVHD prophylaxis. Carefully selecting the donor can help optimize transplant outcomes for recipients of haploidentical donor transplants. Variables usually considered in the donor selection include presence of donor-specific antibodies in the recipient, donor age, donor/recipient gender and ABO combinations, and immunogenic variables, such as natural killer cell alloreactivity or KIR haplotype. Here we provide a comprehensive review of available evidence for selecting haploidentical donors for transplantation, and summarize the recommendations from the European Society for Blood and Marrow Transplantation (EBMT) on donor selection for different transplant platforms.

Published
2020
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23. Correction to: Special issues related to the diagnosis and management of acquired aplastic anemia in countries with restricted resources, a report on behalf of the Eastern Mediterranean Blood and Marrow Transplantation (EMBMT) Group and Severe Aplastic Anemia Working Party of the European Society for Blood and Marrow Transplantation (SAAWP of EBMT)

Author

Iftikhar, Raheel, Ahmad, Parvez, de Latour, Regis, Dufour, Carlo, Risitano, Antonio, Chaudhri, Naeem, Bazarbachi, Ali, De La Fuente, Josu, Höchsmann, Britta, Osman Ahmed, Syed, Gergis, Usama, Elhaddad, Alaa, Halkes, Constantijn, Albeirouti, Bassim, Alotaibi, Sultan, Kulasekararaj, Austin, Alzahrani, Hazzaa, Ben Othman, Tarek, Cesaro, Simone, Alahmari, Ali, Rihani, Rawad, Alshemmari, Salem, Hamidieh, Amir Ali, Bekadja, Mohamed-Amine, Passweg, Jakob, Al-Khabori, Murtadha, Rasheed, Walid, Bacigalupo, Andrea, Chaudhry, Qamar-Un-Nisa, Ljungman, Per, Marsh, Judith, El Fakih, Riad, and Aljurf, Mahmoud

Published
2022
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24. Correction: The European Society for Blood and Marrow Transplantation (EBMT) Consensus Guidelines for the Detection and Treatment of Donor-specific Anti-HLA Antibodies (DSA) in Haploidentical Hematopoietic Cell Transplantation

Author

Ciurea, Stefan O., Cao, Kai, Fernandez-Vina, Marcelo, Kongtim, Piyanuch, Malki, Monzr Al, Fuchs, Ephraim, Luznik, Leo, Huang, Xiao-Jun, Ciceri, Fabio, Locatelli, Franco, Aversa, Franco, Castagna, Luca, Bacigalupo, Andrea, Martelli, Massimo, Blaise, Didier, Handgretinger, Rupert, Roy, Denis-Claude, O’Donnell, Paul, Bashey, Asad, Lazarus, Hillard M., Ballen, Karen, Savani, Bipin N., Mohty, Mohamad, and Nagler, Arnon

Abstract

The original version of this Article contained a typographical error in the spelling of the author Marcelo Fernandez-Vina, which was incorrectly given as Marcelo Fernadez-Vina. This has now been corrected in the PDF and HTML versions of the Article.

Published
2019
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25. Reply to the letter by M Ayas.

Author

Bacigalupo, Andrea

Subjects
*FANCONI'S anemia, *LYMPHOMAS, *LYMPHOPROLIFERATIVE disorders
Abstract

Bone Marrow Transplantation (2002) 31, 313. doi:10.1038/sj.bmt.1703805 [ABSTRACT FROM AUTHOR]

Published
2003
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