1. The EBMT activity survey on hematopoietic-cell transplantation and cellular therapy 2018: CAR-T's come into focus
- Author
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Passweg, J.R., Baldomero, H., Chabannon, C., Basak, G.W., Corbacioglu, S., Duarte, R., Dolstra, H., Lankester, A.C., Mohty, M., Montoto, S., Latour, R.P. de, Snowden, J.A., Styczynski, J., Yakoub-Agha, I., Kroger, N., European Soc Blood Marrow Transpla, UAM. Departamento de Medicina, University Hospital Basel [Basel], Institut Paoli-Calmettes, Fédération nationale des Centres de lutte contre le Cancer (FNCLCC), Medical University of Warsaw - Poland, Universität Regensburg (UR), Hospital Universitario Puerta de Hierro-Majadahonda [Madrid, Spain], Radboud University Medical Center [Nijmegen], Leiden University Medical Center (LUMC), Centre de Recherche Saint-Antoine (CR Saint-Antoine), Sorbonne Université (SU)-Institut National de la Santé et de la Recherche Médicale (INSERM)-CHU Saint-Antoine [AP-HP], Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP)-Sorbonne Université (SU)-Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP)-Sorbonne Université (SU), Barts Health NHS Trust [London, UK], Hopital Saint-Louis [AP-HP] (AP-HP), Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP), Department of Haematology & Department of Oncology, NHS & University of Sheffield, University of Technology and Life Sciences [ Bydgoszcz], CHU Lille, University Hospital Hamburg-Eppendorf, Universitaetsklinikum Hamburg-Eppendorf = University Medical Center Hamburg-Eppendorf [Hamburg] (UKE), Centre de Recherche Saint-Antoine (CRSA), Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Sorbonne Université (SU), and Gestionnaire, HAL Sorbonne Université 5
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[SDV.MHEP.HEM] Life Sciences [q-bio]/Human health and pathology/Hematology ,Oncology ,medicine.medical_specialty ,Myeloid ,Medicina ,Cancer development and immune defence Radboud Institute for Molecular Life Sciences [Radboudumc 2] ,medicine.medical_treatment ,Hematopoietic stem cell transplantation ,Transplantation, Autologous ,Article ,Cell therapy ,03 medical and health sciences ,0302 clinical medicine ,Internal medicine ,hemic and lymphatic diseases ,Medicine ,Leukaemia ,Humans ,Transplantation, Homologous ,Aplastic anemia ,Cellular therapies ,Transplantation ,Haematological cancer ,Receptors, Chimeric Antigen ,European Society for Blood and Marrow Transplantation (EBMT) ,business.industry ,Multiple sclerosis ,Hematopoietic Stem Cell Transplantation ,[SDV.MHEP.HEM]Life Sciences [q-bio]/Human health and pathology/Hematology ,Hematology ,medicine.disease ,Lymphoid malignancies ,3. Good health ,Europe ,Haematopoiesis ,medicine.anatomical_structure ,030220 oncology & carcinogenesis ,Hematopoietic-cell transplantation (HCT) ,Car t cells ,business ,030215 immunology - Abstract
Hematopoietic-cell transplantation (HCT) is widely used for acquired and congenital disorders of the hematopoietic system. Number of transplants performed in Europe and associated countries continues to rise with 47,468 HCT in 42,901 patients [19,630 allogeneic (41%) and 27,838 autologous (59%)] reported by 701 centers in 50 countries in 2018. Main indications were myeloid malignancies 10,679 (25%; 97% allogeneic), lymphoid malignancies 27,318 (64%; 20% allogeneic), solid tumors 1625 (4%; 2.9% allogeneic), and nonmalignant disorders 3063 (7%; 81% allogeneic). This year’s analysis focuses on cellular therapies with the marked growth in CAR T-cell therapies from 151 in 2017 to 301 patients reported in 2018. Other cellular therapy numbers show less significant changes. Important trends in HCT include a 49% increase in allogeneic HCT for chronic phase CML (although transplant numbers remain low) and a 24% increase in aplastic anemia. In autologous HCT, there is an ongoing increase in autoimmune diseases (by 19%), predominantly due to activity in multiple sclerosis. This annual report reflects current activity and highlights important trends, useful for health care planning.
- Published
- 2020