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Your search keyword '"Behre, Gerhard"' showing total 7 results
Start Over Author "Behre, Gerhard" Journal bone marrow transplantation
7 results on '"Behre, Gerhard"'

1. Author Correction: Predicting hepatic complications of allogeneic hematopoietic stem cell transplantation using liver stiffness measurement

Author

Karlas, Thomas, primary, Weiße, Tina, additional, Petroff, David, additional, Beer, Sebastian, additional, Döhring, Christine, additional, Gnatzy, Franziska, additional, Niederwieser, Dietger, additional, Behre, Gerhard, additional, Mössner, Joachim, additional, Fischer, Janett, additional, Tröltzsch, Michael, additional, Wiegand, Johannes, additional, Keim, Volker, additional, and Franke, Georg-Nikolaus, additional

Published
2019
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2. Predicting hepatic complications of allogeneic hematopoietic stem cell transplantation using liver stiffness measurement

Author

Karlas, Thomas, primary, Weiße, Tina, additional, Petroff, David, additional, Beer, Sebastian, additional, Döhring, Christine, additional, Gnatzy, Franziska, additional, Niederwieser, Dietger, additional, Behre, Gerhard, additional, Mössner, Joachim, additional, Fischer, Janett, additional, Tröltzsch, Michael, additional, Wiegand, Johannes, additional, Keim, Volker, additional, and Franke, Georg-Nikolaus, additional

Published
2019
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3. Clinical impact of clonal hematopoiesis in acute myeloid leukemia patients receiving allogeneic transplantation

Author

Grimm, Juliane, primary, Bill, Marius, additional, Jentzsch, Madlen, additional, Beinicke, Stefanie, additional, Häntschel, Janine, additional, Goldmann, Karoline, additional, Schulz, Julia, additional, Cross, Michael, additional, Franke, Georg–Nikolaus, additional, Behre, Gerhard, additional, Vucinic, Vladan, additional, Pönisch, Wolfram, additional, Lange, Thoralf, additional, Niederwieser, Dietger, additional, and Schwind, Sebastian, additional

Published
2018
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4. Prognostic relevance of DNMT3A R882 mutations in AML patients undergoing non-myeloablative conditioning hematopoietic stem cell transplantation

Author

Schmalbrock, Laura K., primary, Bonifacio, Lynn, additional, Bill, Marius, additional, Jentzsch, Madlen, additional, Schubert, Karoline, additional, Grimm, Juliane, additional, Cross, Michael, additional, Lange, Thoralf, additional, Vucinic, Vladan, additional, Pönisch, Wolfram, additional, Behre, Gerhard, additional, Franke, Georg-Nikolaus, additional, Niederwieser, Dietger, additional, and Schwind, Sebastian, additional

Published
2018
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5. Clinical impact of clonal hematopoiesis in acute myeloid leukemia patients receiving allogeneic transplantation

Author

Grimm, Juliane, Bill, Marius, Jentzsch, Madlen, Beinicke, Stefanie, Häntschel, Janine, Goldmann, Karoline, Schulz, Julia, Cross, Michael, Franke, Georg–Nikolaus, Behre, Gerhard, Vucinic, Vladan, Pönisch, Wolfram, Lange, Thoralf, Niederwieser, Dietger, and Schwind, Sebastian

Abstract

Age-related somatic mutations linked to clonal hematopoiesis have been found in apparently healthy individuals and increase the risk of developing hematologic malignancies. In acute myeloid leukemia (AML) the clinical relevance of clonal hematopoiesis remains controversial and data on patients with detectable clonal hematopoiesis, consolidated with hematopoietic stem cell transplantation are limited. We analyzed samples from 113 AML patients in complete remission prior to hematopoietic stem cell transplantation for the presence of clonal hematopoiesis-associated mutations. The results were correlated with clinical and biological data. In complete remission we found 75 mutations previously linked to clonal hematopoiesis in 47 patients (41.6%). Twenty patients had ≥2 mutations linked to clonal hematopoiesis. DNMT3A, TET2, and ASXL1were most frequently mutated. When compared to pre-treatment samples we found variable patterns of mutation persistence depending on the gene mutated. In AML patients after allogeneic hematopoietic stem cell transplantation the presence of clonal hematopoiesis-associated mutations in complete remission did not associate with inferior clinical outcome. This study demonstrates that clonal hematopoiesis is a frequent phenomenon in AML patients. Presence of clonal hematopoiesis has no negative prognostic impact in the context of an allogeneic hematopoietic stem cell transplantation and might be beneficial if certain genes are affected.

Published
2019
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