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Start Over Author "KAWASHIMA N" Journal bone marrow transplantation
10 results on '"KAWASHIMA N"'

5. Increase of bone marrow macrophages and CD8+T lymphocytes predict graft failure after allogeneic bone marrow or cord blood transplantation

Author

Kawashima, N, Terakura, S, Nishiwaki, S, Koyama, D, Ozawa, Y, Ito, M, and Miyamura, K

Abstract

Graft failure (GF) remains an obstacle to survival after allogeneic hematopoietic stem cell transplantation. However, differentiating GF from delayed engraftment (DE) can be difficult. Host CD8+lymphocytes have been reported to mediate graft rejection, but the impact of macrophages on DE or GF is yet to be clarified. Peri-engraftment bone marrow (BM) specimens of 32 adult patients with normal engraftment, DE or GF were retrospectively evaluated to identify the potential associations of CD163+macrophage and CD8+lymphocyte infiltration into BM. The macrophage or CD8+lymphocyte number/total nucleated cell number was defined as the Mac ratio and CD8 ratio, respectively. Both DE and GF groups had significantly higher Mac ratios at day 14 than the normal group (P<0.0001), but no significant difference was observed between the DE and GF groups (P=1.000). The CD8 ratio at day 14 was significantly higher in the GF than in the normal group (P=0.005), whereas the CD8 ratios of the DE and normal groups were similar (P=0.07). A high Mac ratio at day 14 was associated with a risk of DE or subsequent GF. Patients with increased CD8 ratio at day 14 had a further risk of GF. The Mac ratio and the CD8 ratio appear to be well suited for predicting engraftment status.

Published
2017
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9. Iodine staining and p16 immunohistochemistry as a novel screening for secondary esophageal neoplasm after hematopoietic stem cell transplantation.

Author

Sato T, Seto A, Kagaya Y, Kawashima N, Koyama D, Morishita T, Ozawa Y, Miyamura K, Yamaguchi T, Haruta JI, and Ito M

Subjects
Adolescent, Adult, Child, Child, Preschool, Female, Humans, Immunohistochemistry, Infant, Male, Prospective Studies, Biomarkers, Tumor metabolism, Cyclin-Dependent Kinase Inhibitor p16 metabolism, Esophageal Neoplasms metabolism, Esophageal Neoplasms pathology, Hematopoietic Stem Cell Transplantation, Iodine chemistry, Neoplasms, Second Primary metabolism, Staining and Labeling
Published
2018
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10. Increase of bone marrow macrophages and CD8 + T lymphocytes predict graft failure after allogeneic bone marrow or cord blood transplantation.

Author

Kawashima N, Terakura S, Nishiwaki S, Koyama D, Ozawa Y, Ito M, and Miyamura K

Subjects
Adult, Aged, Cell Count, Female, Humans, Male, Middle Aged, Predictive Value of Tests, Prognosis, Retrospective Studies, Transplantation, Homologous, Young Adult, Bone Marrow Transplantation adverse effects, CD8-Positive T-Lymphocytes pathology, Cord Blood Stem Cell Transplantation adverse effects, Graft Rejection diagnosis, Macrophages pathology
Abstract

Graft failure (GF) remains an obstacle to survival after allogeneic hematopoietic stem cell transplantation. However, differentiating GF from delayed engraftment (DE) can be difficult. Host CD8 + lymphocytes have been reported to mediate graft rejection, but the impact of macrophages on DE or GF is yet to be clarified. Peri-engraftment bone marrow (BM) specimens of 32 adult patients with normal engraftment, DE or GF were retrospectively evaluated to identify the potential associations of CD163 + macrophage and CD8 + lymphocyte infiltration into BM. The macrophage or CD8 + lymphocyte number/total nucleated cell number was defined as the Mac ratio and CD8 ratio, respectively. Both DE and GF groups had significantly higher Mac ratios at day 14 than the normal group (P<0.0001), but no significant difference was observed between the DE and GF groups (P=1.000). The CD8 ratio at day 14 was significantly higher in the GF than in the normal group (P=0.005), whereas the CD8 ratios of the DE and normal groups were similar (P=0.07). A high Mac ratio at day 14 was associated with a risk of DE or subsequent GF. Patients with increased CD8 ratio at day 14 had a further risk of GF. The Mac ratio and the CD8 ratio appear to be well suited for predicting engraftment status.

Published
2017
Full Text
View/download PDF

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