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1. Correction: Supportive care during pediatric hematopoietic stem cell transplantation: beyond infectious diseases. A report from workshops on supportive care of the Pediatric Diseases Working Party (PDWP) of the European Society for Blood and Marrow Transplantation (EBMT)

Author

Nava, Tiago, primary, Ansari, Marc, additional, Dalle, Jean-Hugues, additional, de Heredia, Christina Diaz, additional, Güngör, Tayfun, additional, Trigoso, Eugenia, additional, Falkenberg, Ulrike, additional, Bertaina, Alice, additional, Gibson, Brenda, additional, Jarisch, Andrea, additional, Balduzzi, Adriana, additional, Boenig, Halvard, additional, Krivan, Gergely, additional, Vettenranta, Kim, additional, Matic, Toni, additional, Buechner, Jochen, additional, Kalwak, Krzysztof, additional, Lawitschka, Anita, additional, Yesilipek, Akif, additional, Lucchini, Giovanna, additional, Peters, Christina, additional, Turkiewicz, Dominik, additional, Niinimäki, Riitta, additional, Diesch, Tamara, additional, Lehrnbecher, Thomas, additional, Sedlacek, Petr, additional, Hutt, Daphna, additional, Dalissier, Arnaud, additional, Wachowiak, Jacek, additional, Yaniv, Isaac, additional, Stein, Jerry, additional, Yalçin, Koray, additional, Sisinni, Luisa, additional, Deiana, Marco, additional, Ifversen, Marianne, additional, Kuhlen, Michaela, additional, Meisel, Roland, additional, Bakhtiar, Shahrzad, additional, Cesaro, Simone, additional, Willasch, Andre, additional, Corbacioglu, Selim, additional, and Bader, Peter, additional

Published
2020
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2. Supportive care during pediatric hematopoietic stem cell transplantation: beyond infectious diseases. A report from workshops on supportive care of the Pediatric Diseases Working Party (PDWP) of the European Society for Blood and Marrow Transplantation (EBMT)

Author

Nava, Tiago, primary, Ansari, Marc, additional, Dalle, Jean-Hugues, additional, de Heredia, Christina Diaz, additional, Güngör, Tayfun, additional, Trigoso, Eugenia, additional, Falkenberg, Ulrike, additional, Bertaina, Alice, additional, Gibson, Brenda, additional, Jarisch, Andrea, additional, Balduzzi, Adriana, additional, Boenig, Halvard, additional, Krivan, Gergely, additional, Vettenranta, Kim, additional, Matic, Toni, additional, Buechner, Jochen, additional, Kalwak, Krzysztof, additional, Lawitschka, Anita, additional, Yesilipek, Akif, additional, Lucchini, Giovanna, additional, Peters, Christina, additional, Turkiewicz, Dominik, additional, Niinimäki, Riitta, additional, Diesch, Tamara, additional, Lehrnbecher, Thomas, additional, Sedlacek, Petr, additional, Hutt, Daphna, additional, Dalissier, Arnaud, additional, Wachowiak, Jacek, additional, Yaniv, Isaac, additional, Stein, Jerry, additional, Yalçin, Koray, additional, Sisinni, Luisa, additional, Deiana, Marco, additional, Ifversen, Marianne, additional, Kuhlen, Michaela, additional, Meisel, Roland, additional, Bakhtiar, Shahrzad, additional, Cesaro, Simone, additional, Willasch, Andre, additional, Corbacioglu, Selim, additional, and Bader, Peter, additional

Published
2020
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3. Transplant center practices for psychosocial assessment and management of pediatric hematopoietic stem cell donors

Author

Wiener, Lori, primary, Hoag, Jennifer A., additional, Pelletier, Wendy, additional, Shah, Nirali N., additional, Shaw, Bronwen E., additional, Pulsipher, Michael A., additional, Bruce, Jessica, additional, Bader, Peter, additional, Willasch, Andre M., additional, Dalissier, Arnaud, additional, Guilcher, Gregory, additional, Anthias, Chloe, additional, Confer, Dennis L., additional, Sees, Jennifer A., additional, Logan, Brent, additional, and Switzer, Galen E., additional

Published
2019
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4. AlloHSCT in paediatric ALL and AML in complete remission: improvement over time impacted by accreditation?

Author

Bakhtiar, Shahrzad, primary, Salzmann-Manrique, Emilia, additional, Hutter, Martin, additional, Krenn, Thomas, additional, Duerken, Matthias, additional, Faber, Joerg, additional, Reinhard, Harald, additional, Kreyenberg, Hermann, additional, Huenecke, Sabine, additional, Cappel, Claudia, additional, Bremm, Melanie, additional, Pfirrmann, Verena, additional, Merker, Michael, additional, Barnbrock, Anke, additional, Schöning, Stefan, additional, Willasch, Andre Manfred, additional, Rettinger, Eva, additional, Soerensen, Jan, additional, Klingebiel, Thomas Erich, additional, Jarisch, Andrea, additional, and Bader, Peter, additional

Published
2018
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5. Haploidentical allogeneic hematopoietic stem cell transplantation in patients with high-risk soft tissue sarcomas: results of a single-center prospective trial

Author

Merker, Michael, primary, Meister, Michael Torsten, additional, Rettinger, Eva, additional, Jarisch, Andrea, additional, Soerensen, Jan, additional, Willasch, Andre, additional, Huenecke, Sabine, additional, Cappel, Claudia, additional, Bremm, Melanie, additional, Salzmann-Manrique, Emilia, additional, Krenn, Thomas, additional, Rossig, Claudia, additional, Kremens, Bernhard, additional, Koscielniak, Ewa, additional, Klingebiel, Thomas, additional, and Bader, Peter, additional

Published
2018
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6. Myeloablative conditioning for allo-HSCT in pediatric ALL: FTBI or chemotherapy?—A multicenter EBMT-PDWP study

Author

Willasch, Andre Manfred, Peters, Christina, Sedláček, Petr, Dalle, Jean-Hugues, Kitra-Roussou, Vassiliki, Yesilipek, Akif, Wachowiak, Jacek, Lankester, Arjan, Prete, Arcangelo, Hamidieh, Amir Ali, Ifversen, Marianne, Buechner, Jochen, Kriván, Gergely, Hamladji, Rose-Marie, Diaz-de-Heredia, Cristina, Skorobogatova, Elena, Michel, Gérard, Locatelli, Franco, Bertaina, Alice, Veys, Paul, Dupont, Sophie, Or, Reuven, Güngör, Tayfun, Aleinikova, Olga, Sufliarska, Sabina, Sundin, Mikael, Rascon, Jelena, Kaare, Ain, Nemet, Damir, Fagioli, Franca, Klingebiel, Thomas Erich, Styczynski, Jan, Bierings, Marc, Nagy, Kálmán, Abecasis, Manuel, Afanasyev, Boris, Ansari, Marc, Vettenranta, Kim, Alseraihy, Amal, Chybicka, Alicja, Robinson, Stephen, Bertrand, Yves, Kupesiz, Alphan, Ghavamzadeh, Ardeshir, Campos, Antonio, Pichler, Herbert, Dalissier, Arnaud, Labopin, Myriam, Corbacioglu, Selim, Balduzzi, Adriana, Galimard, Jacques-Emmanuel, and Bader, Peter

Abstract

Although most children with acute lymphoblastic leukemia (ALL) receive fractionated total body irradiation (FTBI) as myeloablative conditioning (MAC) for allogeneic hematopoietic stem cell transplantation (allo-HSCT), it is an important matter of debate if chemotherapy can effectively replace FTBI. To compare outcomes after FTBI versus chemotherapy-based conditioning (CC), we performed a retrospective EBMT registry study. Children aged 2–18 years after MAC for first allo-HSCT of bone marrow (BM) or peripheral blood stem cells (PBSC) from matched-related (MRD) or unrelated donors (UD) in first (CR1) or second remission (CR2) between 2000 and 2012 were included. Propensity score weighting was used to control pretreatment imbalances of the observed variables. 3.054 patients were analyzed. CR1 (1.498): median follow-up (FU) after FTBI (1.285) and CC (213) was 6.8 and 6.1 years. Survivals were not significantly different. CR2 (1.556): median FU after FTBI (1.345) and CC (211) was 6.2 years. Outcomes after FTBI were superior as compared with CC with regard to overall survival (OS), leukemia-free survival (LFS), relapse incidence (RI), and nonrelapse mortality (NRM). However, we must emphasize the preliminary character of the results of this retrospective “real-world-practice” study. These findings will be prospectively assessed in the ALL SCTped 2012 FORUM trial.

Published
2020
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7. AlloHSCT in paediatric ALL and AML in complete remission: improvement over time impacted by accreditation?

Author

Bakhtiar, Shahrzad, Salzmann-Manrique, Emilia, Hutter, Martin, Krenn, Thomas, Duerken, Matthias, Faber, Joerg, Reinhard, Harald, Kreyenberg, Hermann, Huenecke, Sabine, Cappel, Claudia, Bremm, Melanie, Pfirrmann, Verena, Merker, Michael, Barnbrock, Anke, Schöning, Stefan, Willasch, Andre Manfred, Rettinger, Eva, Soerensen, Jan, Klingebiel, Thomas Erich, Jarisch, Andrea, and Bader, Peter

Abstract

Allogeneic hematopoietic stem cell transplantation (alloHSCT) has become a well-established treatment option for many patients suffering from malignant and non-malignant diseases. In the past decade, high-resolution HLA-typing, remission surveillance, pre-emptive immune intervention, and standardisation in supportive care measures have substantially improved transplant outcomes. This retrospective study evaluated transplant procedures in 162 paediatric patients with acute lymphoblastic leukaemia (n= 124) or acute myeloid leukaemia (n= 38) who received their first alloHSCT in our institution over an 11-year period. We observed a significant reduction in risk of non-relapse mortality (NRM) over time (HR = 0.34, 95% CI 0.12–0.98; P= 0.05), the 4-year NRM estimate decreased from 20% in 2005–2008 to 7% in 2012–2016 (P= 0.02) and an increase in survival after relapse. There was no significant difference in patients who received a graft from a sibling, haplo, or an unrelated donor with regard to their overall survival (P= 0.45), event-free survival (P= 0.61), and non-relapse mortality (P= 0.19). Our data suggest that a specific transplant infrastructure with a highly experienced team in an accredited transplant centre likely contributes to better transplant outcomes for acute leukaemia patients in complete remission regardless of donor type.

Published
2019
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8. Correction: Myeloablative conditioning for allo-HSCT in pediatric ALL: FTBI or chemotherapy?—A multicenter EBMT-PDWP study

Author

Willasch, Andre Manfred, Peters, Christina, Sedláček, Petr, Dalle, Jean-Hugues, Kitra-Roussou, Vassiliki, Yesilipek, Akif, Wachowiak, Jacek, Lankester, Arjan, Prete, Arcangelo, Hamidieh, Amir Ali, Ifversen, Marianne, Buechner, Jochen, Kriván, Gergely, Hamladji, Rose-Marie, Diaz-de-Heredia, Cristina, Skorobogatova, Elena, Michel, Gérard, Locatelli, Franco, Bertaina, Alice, Veys, Paul, Dupont, Sophie, Or, Reuven, Güngör, Tayfun, Aleinikova, Olga, Sufliarska, Sabina, Sundin, Mikael, Rascon, Jelena, Kaare, Ain, Nemet, Damir, Fagioli, Franca, Klingebiel, Thomas Erich, Styczynski, Jan, Bierings, Marc, Nagy, Kálmán, Abecasis, Manuel, Afanasyev, Boris, Ansari, Marc, Vettenranta, Kim, Alseraihy, Amal, Chybicka, Alicja, Robinson, Stephen, Bertrand, Yves, Kupesiz, Alphan, Ghavamzadeh, Ardeshir, Campos, Antonio, Pichler, Herbert, Dalissier, Arnaud, Labopin, Myriam, Corbacioglu, Selim, Balduzzi, Adriana, Galimard, Jacques-Emmanuel, and Bader, Peter

Published
2021
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