1. Endothelial damage caused by cytomegalovirus and human herpesvirus-6
- Author
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Akihisa Kanamaru, Takeshi Wakae, Yoshinobu Takemoto, Masaya Okada, T Okamoto, Eizo Kakishita, Ako Mori, Yoshihiro Fujimori, and Hiroyuki Takatsuka
- Subjects
Adult ,Male ,Thrombotic microangiopathy ,Adolescent ,Herpesvirus 6, Human ,viruses ,Acyclovir ,Roseolovirus Infections ,medicine.disease_cause ,Thrombomodulin ,Antiviral Agents ,Herpesviridae ,Virus ,Betaherpesvirinae ,medicine ,Humans ,Bone Marrow Transplantation ,Transplantation ,biology ,business.industry ,virus diseases ,Thrombosis ,Hematology ,Middle Aged ,medicine.disease ,biology.organism_classification ,Virology ,Molecular biology ,Cytomegalovirus Infections ,Female ,Human herpesvirus 6 ,Endothelium, Vascular ,business ,Plasminogen activator - Abstract
Infection with cytomegalovirus (CMV) or human herpesvirus-6 (HHV-6) may have a role in vascular endothelial damage after bone marrow transplantation (BMT). In total, 41 patients who underwent BMT were classified into four groups (12, 10, 7, and 12 patients who were infected with both CMV and HHV-6, CMV alone, HHV-6, and neither virus, respectively). Levels of thrombomodulin, plasminogen activator inhibitor-1, and cyclic GMP were 7.5+/-1.7 FU/ml, 76.4+/-24.1 ng/ml, and 9.51+/-1.1 pmol/ml, respectively, in the patients with both viruses, while the respective values were 2.9+/-0.67 FU/ml, 33.8+/-8.09 ng/ml, and 2.90+/-1.4 pmol/ml in patients infected with CMV alone, 4.8+/-0.96 FU/ml, 47.7+/-9.21 ng/ml, and 5.48+/-0.55 pmol/ml in patients with HHV-6 alone, and 1.6+/-0.39, 17.5+/-7.88 ng/ml, and 0.45+/-0.3 in those with neither virus. All three markers were significantly higher in the three groups with at least one virus than in the uninfected patients (P
- Published
- 2003