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Staphylococcal enterotoxin A (SEA) is known as a T cell superantigen, with well-characterized neurobiological and endocrine effects. Using a spatial navigation form of Morris water maze (MWM) training, we previously showed that SEA had no effect on initial MWM learning, but one month later, SEA treated mice showed improved reconsolidation of MWM learning (Woodruff et al., 2010). We have tested whether this reconsolidation effect is specific to a prior learning task, or generalizes to a new task. Male C57BL/6J mice were given 5 μg SEA ( N = 8) or Saline ( N = 8) and then subjected to MWM hidden platform training. Two weeks after the final MWM training, mice were subjected to 8 days of water-based radial arm maze (wRAM) training. The results showed no major SEA effect on initial MWM learning. Further, wRAM learning was not improved in SEA-treated mice. Additional experiments demonstrated that operant-based impulsivity testing was modified by SEA treatment ( N = 8), showing that beginning at four days after injection with SEA, correct responding for a signal-associated food reward was impaired, when compared to saline-treated mice ( N = 8). This may be due to the onset of impulsivity and/or cognitive disruption of rule parameters. Collectively, the neurobiological effects of SEA, which affect limbic brain areas, produce a variety of different learning and memory outcomes, which depend on the type of behavioral paradigm utilized. [ABSTRACT FROM AUTHOR]