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1. The spectrum of complement pathway activation is integral to the pathogenesis of severe COVID-19.

Author

Magro, Cynthia and Nuovo, Gerard

Subjects
*COMPLEMENT activation, *ANTIPHOSPHOLIPID syndrome, *COVID-19, *SARS-CoV-2, *HEMOLYTIC-uremic syndrome
Abstract

We read with interest the paper by Lee I et al i .[1] in which they describe widespread microvascular damage marked by endothelial cell damage/activation, microthrombi, complement activation, and disruption of the blood-brain barrier (BBB). Endothelial cell damage is the central part of COVID-19 and a mouse model induced by injection of the S1 subunit of the spike protein. [Extracted from the article]

Published
2022
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