1. Hyperglycaemia and the outcome of stroke
- Author
-
Kari Murros and Antti J. Metso
- Subjects
endocrine system ,medicine.medical_specialty ,Lacunar stroke ,endocrine system diseases ,business.industry ,digestive, oral, and skin physiology ,nutritional and metabolic diseases ,medicine.disease ,Neuroprotection ,Surgery ,Internal medicine ,Ischaemic stroke ,medicine ,Cardiology ,cardiovascular diseases ,Neurology (clinical) ,Serum glucose level ,business ,Stroke - Abstract
We read with great interest the article by Uyttenboogaart and co-workers on the association of serum glucose level with outcome in acute ischaemic stroke. In their multivariate analysis hyperglycaemia (glucose >8 mmol/l) was associated with worse functional outcome in a concentration-dependent manner in non-lacunar stroke, whereas in lacunar stroke hyperglycaemia was associated with favourable outcome, this beneficial effect diminishing with more severe hyperglycaemia (>12 mmol/l). Although Uyttenboogart and colleagues creditably discuss the potential neuroprotective effect of lactate produced by astrocytes, they fail in their conclusions stating that ‘hyperglycaemia has a detrimental effect in non-lacunar stroke, but moderate hyperglycaemia …
- Published
- 2007