1. Longitudinal brain metabolic changes from amnestic mild cognitive impairment to Alzheimer's disease
- Author
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Marine Fouquet, Fausto Viader, Francis Eustache, Brigitte Landeau, Florence Mézenge, Gaël Chételat, Jean-Claude Baron, V. de la Sayette, Edouard Duchesnay, B. Desgranges, Neuropsychologie cognitive et neuroanatomie fonctionnelles de la mémoire humaine, Université de Caen Normandie (UNICAEN), Normandie Université (NU)-Normandie Université (NU)-École pratique des hautes études (EPHE), Université Paris sciences et lettres (PSL)-Université Paris sciences et lettres (PSL)-Institut National de la Santé et de la Recherche Médicale (INSERM), Laboratoire de Neuroimagerie Assistée par Ordinateur (LNAO), Commissariat à l'énergie atomique et aux énergies alternatives (CEA), Centre de Recherches sur la Cognition et l'Apprentissage (CeRCA), Université de Poitiers-Université de Tours (UT)-Centre National de la Recherche Scientifique (CNRS), Department of Clinical Neurosciences [Cambridge], University of Cambridge [UK] (CAM), Centre National de la Recherche Scientifique (CNRS)-Université de Tours-Université de Poitiers, Eustache, Francis, and Normandie Université (NU)-Normandie Université (NU)-École Pratique des Hautes Études (EPHE)
- Subjects
Male ,Cingulate cortex ,Precuneus ,Disease ,Neuropsychological Tests ,Audiology ,Brain mapping ,MESH: Magnetic Resonance Imaging ,MESH: Aged, 80 and over ,0302 clinical medicine ,MESH: Fluorodeoxyglucose F18 ,Cognitive decline ,Cognitive impairment ,10. No inequality ,Prefrontal cortex ,MESH: Brain Mapping ,Aged, 80 and over ,MESH: Aged ,Brain Mapping ,0303 health sciences ,MESH: Middle Aged ,longitudinal study ,Brain ,MESH: Neuropsychological Tests ,MESH: Follow-Up Studies ,Middle Aged ,Magnetic Resonance Imaging ,MESH: Positron-Emission Tomography ,medicine.anatomical_structure ,Neurology ,Disease Progression ,Cardiology ,Female ,MESH: Disease Progression ,[SDV.NEU]Life Sciences [q-bio]/Neurons and Cognition [q-bio.NC] ,Alzheimer's disease ,MESH: Amnesia ,Psychology ,medicine.medical_specialty ,Cognitive Neuroscience ,Uncinate fasciculus ,Article ,MESH: Brain ,03 medical and health sciences ,Alzheimer Disease ,Fluorodeoxyglucose F18 ,Internal medicine ,Image Interpretation, Computer-Assisted ,medicine ,Humans ,[SDV.NEU] Life Sciences [q-bio]/Neurons and Cognition [q-bio.NC] ,Aged ,030304 developmental biology ,MESH: Humans ,business.industry ,amnestic Mild Cognitive Impairment ,medicine.disease ,MESH: Male ,MESH: Cognition Disorders ,18FDG-PET monitoring ,Positron-Emission Tomography ,Posterior cingulate ,Amnesia ,Neurology (clinical) ,Cognition Disorders ,ventro-medial prefrontal cortex ,business ,MESH: Image Interpretation, Computer-Assisted ,MESH: Female ,Neuroscience ,MESH: Alzheimer Disease ,030217 neurology & neurosurgery ,Follow-Up Studies - Abstract
International audience; A sensitive marker for monitoring progression of early Alzheimer's disease would help to develop and test new therapeutic strategies. The present study is aimed at investigating brain metabolism changes over time, as a potential monitoring marker, in patients with amnestic mild cognitive impairment, according to their clinical outcome (converters or non-converters), and in relation to their cognitive decline. Seventeen amnestic mild cognitive impairment patients underwent magnetic resonance imaging and 18FDG-positron emission tomography scans both at inclusion and 18 months later. Baseline and follow-up positron emission tomography data were corrected for partial volume effects and spatially normalized using magnetic resonance imaging data, scaled to the vermis and compared using SPM2. 'PET-PAC' maps reflecting metabolic per cent annual changes were created for correlation analyses with cognitive decline. In the whole sample, the greatest metabolic decrease concerned the posterior cingulate-precuneus area. Converters had significantly greater metabolic decrease than non-converters in two ventro-medial prefrontal areas, the subgenual (BA25) and anterior cingulate (BA24/32). PET-PAC in BA25 and BA24/32 combined allowed complete between-group discrimination. BA25 PET-PAC significantly correlated with both cognitive decline and PET-PAC in the hippocampal region and temporal pole, while BA24/32 PET-PAC correlated with posterior cingulate PET-PAC. Finally, the metabolic change in BA8/9/10 was inversely related to that in BA25 and showed relative increase with cognitive decline, suggesting that compensatory processes may occur in this dorso-medial prefrontal region. The observed ventro-medial prefrontal disruption is likely to reflect disconnection from the hippocampus, both indirectly through the cingulum bundle and posterior cingulate cortex for BA24/32, and directly through the uncinate fasciculus for BA25. Altogether, our findings emphasize the potential of 18FDG-positron emission tomography for monitoring early Alzheimer's disease progression.
- Published
- 2009
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