1. Disrupted brain network functional dynamics and hyper-correlation of structural and functional connectome topology in patients with breast cancer prior to treatment
- Author
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Vikram Rao, Marjorie Adams, Shelli R. Kesler, Melissa Packer, Douglas W. Blayney, Ashley M. Henneghan, and Oxana Palesh
- Subjects
Adult ,cognition ,brain ,Breast Neoplasms ,Topology ,Affect (psychology) ,03 medical and health sciences ,Behavioral Neuroscience ,0302 clinical medicine ,Breast cancer ,Neuroimaging ,medicine ,Humans ,cancer ,Aged ,Original Research ,neuroimaging ,medicine.diagnostic_test ,connectome ,fMRI ,Cancer ,Cognition ,Magnetic resonance imaging ,Middle Aged ,medicine.disease ,Magnetic Resonance Imaging ,3. Good health ,Cognitive test ,030220 oncology & carcinogenesis ,Connectome ,Female ,Nerve Net ,Psychology ,030217 neurology & neurosurgery ,MRI - Abstract
Introduction Several previous studies have demonstrated that cancer chemotherapy is associated with brain injury and cognitive dysfunction. However, evidence suggests that cancer pathogenesis alone may play a role, even in non-CNS cancers. Methods Using a multimodal neuroimaging approach, we measured structural and functional connectome topology as well as functional network dynamics in newly diagnosed patients with breast cancer. Our study involved a novel, pretreatment assessment that occurred prior to the initiation of any cancer therapies, including surgery with anesthesia. We enrolled 74 patients with breast cancer age 29–65 and 50 frequency-matched healthy female controls who underwent anatomic and resting-state functional MRI as well as cognitive testing. Results Compared to controls, patients with breast cancer demonstrated significantly lower functional network dynamics (p = .046) and cognitive functioning (p
- Published
- 2016