1. Admission circulating monocytes level is an independent predictor of outcome in traumatic brain injury.
- Author
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Li, Zhiqi, Wu, Xing, Wu, Xuehai, Yu, Jian, Yuan, Qiang, Du, Zhuoying, and Hu, Jin
- Subjects
BIOMARKERS ,BLOOD testing ,BLOOD sugar ,BRAIN injuries ,CONFIDENCE intervals ,HEMOGLOBINS ,HOSPITAL admission & discharge ,MONOCYTES ,MULTIVARIATE analysis ,HEALTH outcome assessment ,PATIENTS ,STATISTICS ,SEVERITY of illness index ,GLASGOW Coma Scale ,ODDS ratio ,PROGNOSIS - Abstract
Objective: The aim of this study was to assess the prognostic value of admission immune cell levels in the peripheral blood in determining outcomes in patients with TBI. Method: We studied 141 adult patients with mild-to-severe TBI (Glasgow Coma Scale (GCS) 3-15). Patient outcome was assessed using the Extended Glasgow Outcome Scale (GOSE) at 6 months post-injury. The area under the curve (AUC) was used to evaluate the predictive ability of immune cell levels. Uni- and multivariate analyses were performed to assess the independent predictors of 6-month outcome. Results: We found that admission monocyte count was not only a better predictor (AUC = 0.778; 95% confidence interval (CI), 0.679-0.858) of favourable outcomes (GOSE 5-8) at 6 months post-injury than were admission haemoglobin (AUC = 0.629; 95% CI, 0.522-0.728) and blood glucose (AUC = 0.616; 95% CI, 0.508-0.716) levels for patients with moderate-to-severe TBI (GCS ≤ 12), but also an independent predictor of 6-month outcome (adjusted odds ratio, 1.35; 95% CI, 1.10-1.65; p = 0.004). Conclusions: The present study suggests that an increase in admission monocyte count is correlated with a favourable 6-month outcome in patients with moderate-to-severe TBI. [ABSTRACT FROM AUTHOR]
- Published
- 2018
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