1. Fructose-1,6-bisphosphate reduces ATP loss from hypoxic astrocytes
- Author
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George A. Gregory, Albert C. H. Yu, Frank A. Welsh, and Pak H. Chan
- Subjects
Fructose 1,6-bisphosphate ,Biology ,chemistry.chemical_compound ,Adenosine Triphosphate ,Lactate dehydrogenase ,Fructosediphosphates ,medicine ,Animals ,Molecular Biology ,Cells, Cultured ,Cerebral Cortex ,General Neuroscience ,Atp content ,Rats, Inbred Strains ,Hypoxia (medical) ,Cell Hypoxia ,Rats ,medicine.anatomical_structure ,chemistry ,Biochemistry ,Cell culture ,Astrocytes ,Neurology (clinical) ,Hexosediphosphates ,medicine.symptom ,Adenosine triphosphate ,Developmental Biology ,Astrocyte - Abstract
Hypoxia caused injury and metabolic dysfunction of astrocytes, as indicated by a time-dependent loss of lactate dehydrogenase (LDH) activity and ATP content. The combination of 3.5 mM fructose-1,6-bisphosphate (FBP) and 7.5 mM glucose (GLC) reduced the decrease of ATP and prevented the loss of LDH. These data indicate that the combination of GLC + FBP protects astrocytes from hypoxia. The results also suggest that the maintainance of ATP concentration is the mechanism by which FBP prevents hypoxic injury.
- Published
- 1990
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