1. Individual differences in the functional neuroanatomy of inhibitory control
- Author
-
Kevin Murphy, Clare Kelly, Robert Hester, Hugh Garavan, and Catherine Fassbender
- Subjects
Adult ,Time Factors ,Adolescent ,Brain activity and meditation ,Central nervous system ,Individuality ,Brain mapping ,medicine ,Image Processing, Computer-Assisted ,Humans ,Molecular Biology ,Evoked Potentials ,Anterior cingulate cortex ,Analysis of Variance ,Brain Mapping ,Working memory ,General Neuroscience ,Brain ,Electroencephalography ,Middle Aged ,Executive functions ,Magnetic Resonance Imaging ,Functional imaging ,Oxygen ,Inhibition, Psychological ,medicine.anatomical_structure ,Female ,Neurology (clinical) ,Analysis of variance ,Psychology ,Neuroscience ,Photic Stimulation ,Developmental Biology - Abstract
We combined the data of five event-related fMRI studies of response inhibition. The re-analysis (n = 71) revealed response inhibition to be accomplished by a largely right hemisphere network of prefrontal, parietal, subcortical and midline regions, with converging evidence pointing to the particular importance of the right frontal operculum. Functional differences were observed between the sexes with greater activity in females in many of these cortical regions. Despite the relatively narrow age range (18-46), cortical activity, on the whole, tended to increase with age, echoing a pattern of functional recruitment often observed in the elderly. More absent minded subjects showed greater activity in fronto-parietal areas, while speed of Go trial responses produced a varied pattern of activation differences in more posterior and subcortical areas. Although response inhibition produces robust activation in a discrete network of brain regions, these results reveal that individual differences impact on the relative contribution made by the nodes of this network.
- Published
- 2005