1. White Matter Change Revealed by Diffusion Tensor Imaging in Gliomas
- Author
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Chun Kee Chung, Hee-Won Jung, Chul-Kee Park, Young Il Won, Chi Heon Kim, Jongmin Lee, and Bang-Bon Koo
- Subjects
Internal capsule ,030218 nuclear medicine & medical imaging ,White matter ,03 medical and health sciences ,0302 clinical medicine ,Magnetic resonance imaging ,Glioma ,Fractional anisotropy ,medicine ,General Environmental Science ,Pyramidal tracts ,medicine.diagnostic_test ,business.industry ,medicine.disease ,medicine.anatomical_structure ,Diffusion tensor imaging ,Tumor progression ,General Earth and Planetary Sciences ,Original Article ,Nuclear medicine ,business ,030217 neurology & neurosurgery ,Diffusion MRI - Abstract
Background Tumor-related white matter change is detected at late stages with magnetic reso nance imaging (MRI), when mass effect or prominent edema is present. We analyzed if diffusion tensor imaging (DTI) white matter change earlier than conventional MRI. Methods Twenty-six patients with gliomas (World Health Organization grade II, 5; grade III, 12; and grade IV, 9) within 2 cm from the posterior limb of the internal capsule (IC) were studied. Fifteen normal adults were enrolled as controls. Fluid attenuation inversion recovery MRI showed a high signal change at the posterior limb of the IC (HSIC) in 9 patients with grade III or IV gliomas. We classified the gliomas as WHO grade II (gliomas II), grade III or IV without HSIC [gliomas III/IV(-)] and grade III or IV with HSIC [gliomas III/IV(+)], as an indicator of the increase in the severity of the white matter changes. Fractional anisotropy (FA) and apparent diffusion coefficients (ADC) were calculated for the pyramidal tract. Tumor progression along pyramidal tract was evaluated by follow-up MRI in 16 patients at 40±18 months. Results FA showed no significant difference between gliomas II and control (p=0.694), but was lower in gliomas III/IV(-) and gliomas III/IV(+) (p
- Published
- 2016