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Start Over Author "Nick Orr" Journal breast cancer research
3 results on '"Nick Orr"'

1. Common variants in breast cancer risk loci predispose to distinct tumor subtypes

Author

Thomas U. Ahearn, Haoyu Zhang, Kyriaki Michailidou, Roger L. Milne, Manjeet K. Bolla, Joe Dennis, Alison M. Dunning, Michael Lush, Qin Wang, Irene L. Andrulis, Hoda Anton-Culver, Volker Arndt, Kristan J. Aronson, Paul L. Auer, Annelie Augustinsson, Adinda Baten, Heiko Becher, Sabine Behrens, Javier Benitez, Marina Bermisheva, Carl Blomqvist, Stig E. Bojesen, Bernardo Bonanni, Anne-Lise Børresen-Dale, Hiltrud Brauch, Hermann Brenner, Angela Brooks-Wilson, Thomas Brüning, Barbara Burwinkel, Saundra S. Buys, Federico Canzian, Jose E. Castelao, Jenny Chang-Claude, Stephen J. Chanock, Georgia Chenevix-Trench, Christine L. Clarke, NBCS Collaborators, J. Margriet Collée, Angela Cox, Simon S. Cross, Kamila Czene, Mary B. Daly, Peter Devilee, Thilo Dörk, Miriam Dwek, Diana M. Eccles, D. Gareth Evans, Peter A. Fasching, Jonine Figueroa, Giuseppe Floris, Manuela Gago-Dominguez, Susan M. Gapstur, José A. García-Sáenz, Mia M. Gaudet, Graham G. Giles, Mark S. Goldberg, Anna González-Neira, Grethe I. Grenaker Alnæs, Mervi Grip, Pascal Guénel, Christopher A. Haiman, Per Hall, Ute Hamann, Elaine F. Harkness, Bernadette A. M. Heemskerk-Gerritsen, Bernd Holleczek, Antoinette Hollestelle, Maartje J. Hooning, Robert N. Hoover, John L. Hopper, Anthony Howell, ABCTB Investigators, kConFab/AOCS Investigators, Milena Jakimovska, Anna Jakubowska, Esther M. John, Michael E. Jones, Audrey Jung, Rudolf Kaaks, Saila Kauppila, Renske Keeman, Elza Khusnutdinova, Cari M. Kitahara, Yon-Dschun Ko, Stella Koutros, Vessela N. Kristensen, Ute Krüger, Katerina Kubelka-Sabit, Allison W. Kurian, Kyriacos Kyriacou, Diether Lambrechts, Derrick G. Lee, Annika Lindblom, Martha Linet, Jolanta Lissowska, Ana Llaneza, Wing-Yee Lo, Robert J. MacInnis, Arto Mannermaa, Mehdi Manoochehri, Sara Margolin, Maria Elena Martinez, Catriona McLean, Alfons Meindl, Usha Menon, Heli Nevanlinna, William G. Newman, Jesse Nodora, Kenneth Offit, Håkan Olsson, Nick Orr, Tjoung-Won Park-Simon, Alpa V. Patel, Julian Peto, Guillermo Pita, Dijana Plaseska-Karanfilska, Ross Prentice, Kevin Punie, Katri Pylkäs, Paolo Radice, Gad Rennert, Atocha Romero, Thomas Rüdiger, Emmanouil Saloustros, Sarah Sampson, Dale P. Sandler, Elinor J. Sawyer, Rita K. Schmutzler, Minouk J. Schoemaker, Ben Schöttker, Mark E. Sherman, Xiao-Ou Shu, Snezhana Smichkoska, Melissa C. Southey, John J. Spinelli, Anthony J. Swerdlow, Rulla M. Tamimi, William J. Tapper, Jack A. Taylor, Lauren R. Teras, Mary Beth Terry, Diana Torres, Melissa A. Troester, Celine M. Vachon, Carolien H. M. van Deurzen, Elke M. van Veen, Philippe Wagner, Clarice R. Weinberg, Camilla Wendt, Jelle Wesseling, Robert Winqvist, Alicja Wolk, Xiaohong R. Yang, Wei Zheng, Fergus J. Couch, Jacques Simard, Peter Kraft, Douglas F. Easton, Paul D. P. Pharoah, Marjanka K. Schmidt, Montserrat García-Closas, and Nilanjan Chatterjee

Subjects
Breast cancer, Etiologic heterogeneity, Genetic predisposition, Common breast cancer susceptibility variants, Neoplasms. Tumors. Oncology. Including cancer and carcinogens, RC254-282
Abstract

Abstract Background Genome-wide association studies (GWAS) have identified multiple common breast cancer susceptibility variants. Many of these variants have differential associations by estrogen receptor (ER) status, but how these variants relate with other tumor features and intrinsic molecular subtypes is unclear. Methods Among 106,571 invasive breast cancer cases and 95,762 controls of European ancestry with data on 173 breast cancer variants identified in previous GWAS, we used novel two-stage polytomous logistic regression models to evaluate variants in relation to multiple tumor features (ER, progesterone receptor (PR), human epidermal growth factor receptor 2 (HER2) and grade) adjusting for each other, and to intrinsic-like subtypes. Results Eighty-five of 173 variants were associated with at least one tumor feature (false discovery rate

Published
2022
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2. Association of germline genetic variants with breast cancer-specific survival in patient subgroups defined by clinic-pathological variables related to tumor biology and type of systemic treatment

Author

Anna Morra, Maria Escala-Garcia, Jonathan Beesley, Renske Keeman, Sander Canisius, Thomas U. Ahearn, Irene L. Andrulis, Hoda Anton-Culver, Volker Arndt, Paul L. Auer, Annelie Augustinsson, Laura E. Beane Freeman, Heiko Becher, Matthias W. Beckmann, Sabine Behrens, Stig E. Bojesen, Manjeet K. Bolla, Hermann Brenner, Thomas Brüning, Saundra S. Buys, Bette Caan, Daniele Campa, Federico Canzian, Jose E. Castelao, Jenny Chang-Claude, Stephen J. Chanock, Ting-Yuan David Cheng, Christine L. Clarke, NBCS Collaborators, Sarah V. Colonna, Fergus J. Couch, Angela Cox, Simon S. Cross, Kamila Czene, Mary B. Daly, Joe Dennis, Thilo Dörk, Laure Dossus, Alison M. Dunning, Miriam Dwek, Diana M. Eccles, Arif B. Ekici, A. Heather Eliassen, Mikael Eriksson, D. Gareth Evans, Peter A. Fasching, Henrik Flyger, Lin Fritschi, Manuela Gago-Dominguez, José A. García-Sáenz, Graham G. Giles, Mervi Grip, Pascal Guénel, Melanie Gündert, Eric Hahnen, Christopher A. Haiman, Niclas Håkansson, Per Hall, Ute Hamann, Steven N. Hart, Jaana M. Hartikainen, Arndt Hartmann, Wei He, Maartje J. Hooning, Reiner Hoppe, John L. Hopper, Anthony Howell, David J. Hunter, ABCTB Investigators, kConFab Investigators, Agnes Jager, Anna Jakubowska, Wolfgang Janni, Esther M. John, Audrey Y. Jung, Rudolf Kaaks, Machteld Keupers, Cari M. Kitahara, Stella Koutros, Peter Kraft, Vessela N. Kristensen, Allison W. Kurian, James V. Lacey, Diether Lambrechts, Loic Le Marchand, Annika Lindblom, Martha Linet, Robert N. Luben, Jan Lubiński, Michael Lush, Arto Mannermaa, Mehdi Manoochehri, Sara Margolin, John W. M. Martens, Maria Elena Martinez, Dimitrios Mavroudis, Kyriaki Michailidou, Roger L. Milne, Anna Marie Mulligan, Taru A. Muranen, Heli Nevanlinna, William G. Newman, Sune F. Nielsen, Børge G. Nordestgaard, Andrew F. Olshan, Håkan Olsson, Nick Orr, Tjoung-Won Park-Simon, Alpa V. Patel, Bernard Peissel, Paolo Peterlongo, Dijana Plaseska-Karanfilska, Karolina Prajzendanc, Ross Prentice, Nadege Presneau, Brigitte Rack, Gad Rennert, Hedy S. Rennert, Valerie Rhenius, Atocha Romero, Rebecca Roylance, Matthias Ruebner, Emmanouil Saloustros, Elinor J. Sawyer, Rita K. Schmutzler, Andreas Schneeweiss, Christopher Scott, Mitul Shah, Snezhana Smichkoska, Melissa C. Southey, Jennifer Stone, Harald Surowy, Anthony J. Swerdlow, Rulla M. Tamimi, William J. Tapper, Lauren R. Teras, Mary Beth Terry, Rob A. E. M. Tollenaar, Ian Tomlinson, Melissa A. Troester, Thérèse Truong, Celine M. Vachon, Qin Wang, Amber N. Hurson, Robert Winqvist, Alicja Wolk, Argyrios Ziogas, Hiltrud Brauch, Montserrat García-Closas, Paul D. P. Pharoah, Douglas F. Easton, Georgia Chenevix-Trench, and Marjanka K. Schmidt

Subjects
Common germline genetic variants, Breast cancer-specific survival, Patient subgroups, Tumor biology, Systemic treatment, Neoplasms. Tumors. Oncology. Including cancer and carcinogens, RC254-282
Abstract

Abstract Background Given the high heterogeneity among breast tumors, associations between common germline genetic variants and survival that may exist within specific subgroups could go undetected in an unstratified set of breast cancer patients. Methods We performed genome-wide association analyses within 15 subgroups of breast cancer patients based on prognostic factors, including hormone receptors, tumor grade, age, and type of systemic treatment. Analyses were based on 91,686 female patients of European ancestry from the Breast Cancer Association Consortium, including 7531 breast cancer-specific deaths over a median follow-up of 8.1 years. Cox regression was used to assess associations of common germline variants with 15-year and 5-year breast cancer-specific survival. We assessed the probability of these associations being true positives via the Bayesian false discovery probability (BFDP

Published
2021
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3. Genetic variation at CYP3A is associated with age at menarche and breast cancer risk: a case-control study

Author

Xianshu Wang, Susan L. Slager, Bernardo Bonanni, Katarzyna Durda, Sze Yee Phuah, M. Pilar Zamora, Dong Young Noh, Gillian S. Dite, Chiun-Sheng Huang, Lorna Gibson, Argyrios Ziogas, Artitaya Lophatananon, Pascal Guénel, Valeria Pensotti, Vernon S. Pankratz, Graham G. Giles, Anna H. Wu, Natalia Antonenkova, Daniel Vincent, Antoinette Hollestelle, Malcolm W.R. Reed, Hans Ulrich Ulmer, Vesa Kataja, Dieter Flesch-Janys, Hermann Brenner, Hui Miao, Nichola Johnson, Rita K. Schmutzler, Francois Bacot, Hans Wildiers, Thilo Dörk, Mark S. Goldberg, Julian Peto, Thomas Rüdiger, Cox A, Børge G. Nordestgaard, Patrick Neven, Vessela N. Kristensen, Barbara Burwinkel, David Van Den Berg, Craig Luccarini, Joe Dennis, Emilie Cordina, Dominiek Smeets, Natalia Bogdanova, Jaana M. Hartikainen, Stefan Nickels, Jean Wang, Kyriaki Michailidou, Henrik Flyger, Daniel C. Tessier, Paolo Radice, Stephen J. Chanock, Mark E. Sherman, Arif B. Ekici, Matthias W. Beckmann, William Blot, Daehee Kang, Christopher A. Haiman, Florence Menegaux, Gianluca Severi, Mervi Grip, Ben P. Haynes, Melissa C. Southey, Simon S. Cross, Montserrat Garcia-Closas, Mitch Dowsett, Jenny Chang-Claude, Drakoulis Yannoukakos, Celine M. Vachon, Isabel dos Santos Silva, Elinor J. Sawyer, Katri Pylkäs, Cheng Har Yip, Joerg Heil, Manjeet K. Bolla, Heiko Müller, Jyh Cherng Yu, Janet E. Olson, Wei Zheng, Carl Blomqvist, Yon Ko, Minouk J. Schoemaker, Christof Sohn, Ming-Feng Hou, Anna González-Neira, Ian Tomlinson, Thérèse Truong, Diether Lambrechts, Mikael Hartman, Douglas F. Easton, Chen-Yang Shen, Andreas Schneeweiss, Javier Benitez, Amanda E. Toland, Anna Marie Mulligan, Jacques Simard, Suleeporn Sangrajrang, Robert Winqvist, Stig E. Bojesen, Nick Orr, Martine Dumont, Heli Nevanlinna, James McKay, Valerie Gaborieau, Keitaro Matsuo, Christina Clarke Dur, Aida Karina Dieffenbach, Jonathan Beesley, Grethe I. Grenaker Alnæs, Taru A. Muranen, Paolo Peterlongo, Marjanka K. Schmidt, Peter Devillee, Olivia Fletcher, Frederik Marmé, Anna Jakubowska, Paul D.P. Pharoah, Paul Brennan, Jolanta Lissowska, Nils Schoof, Ji Yeob Choi, Hoda Anton-Culver, Femke Atsma, Per Hall, Anja Rudolph, Ian W. Brock, Elizabeth Folkerd, Veli-Matti Kosma, Soo H. Teo, Arto Mannermaa, Chiu-Chen Tseng, Fergus J. Couch, Anne Lise Børresen-Dale, Anthony J. Swerdlow, Hiltrud Brauch, Jose Ignacio Arias Perez, Frank Dudbridge, Lisa B. Signorello, Madeleine M. A. Tilanus-Linthorst, Jonine D. Figueroa, Christina Justenhoven, Ute Hamann, Julia A. Knight, Peter A. Fasching, Alan Ashworth, Stefan P. Renner, Zachary S. Fredericksen, Wei-Yen Lim, Sue K. Park, Annegien Broeks, Georgia Chenevix-Trench, Jan Lubinski, Gord Glendon, Kristiina Aittomäki, Maartje J. Hooning, Jianjun Liu, Volker Arndt, Alfons Meindl, Leslie Bernstein, Laura Baglietto, Mitul Shah, Belinda K. Cornes, John L. Hopper, Penny Soucy, Katarzyna Jaworska-Bieniek, Alison M. Dunning, Claus R. Bartram, Roger L. Milne, Michael Jones, Kenneth Muir, Irene L. Andrulis, Arja Jukkola-Vuorinen, Annika Lindblom, Michael J. Kerin, Nicola Miller, Carmel Apicella, Asta Försti, Anthony Tang, Laura J. van't Veer, Rogier A. Oldenburg, Neurology, Medical Oncology, Clinical Genetics, Surgery, and Cardiothoracic Surgery

Subjects
Physiology, chemistry.chemical_compound, 610 Medical sciences Medicine, 0302 clinical medicine, Risk Factors, Medizinische Fakultät, Genotype, Cytochrome P-450 CYP3A, Age of Onset, Reproductive History, Medicine(all), 0303 health sciences, Age Factors, twins, Middle Aged, 3. Good health, steroid-hormones, 030220 oncology & carcinogenesis, loci, Menarche, Veterinary (all), Female, Research Article, Adult, medicine.medical_specialty, premenopausal women, Breast Neoplasms, Estrone, Single-nucleotide polymorphism, Polymorphism, Single Nucleotide, White People, Healthcare improvement science Radboud Institute for Health Sciences [Radboudumc 18], 03 medical and health sciences, Breast cancer, SDG 3 - Good Health and Well-being, estradiol, medicine, Humans, Genetic Predisposition to Disease, ddc:610, Genetic Association Studies, Aged, 030304 developmental biology, Gynecology, business.industry, Case-control study, medicine.disease, Clinical research, Premenopause, chemistry, sex-hormone levels, Cancer and Oncology, genome-wide association, Age of onset, business, serum
Abstract

Introduction We have previously shown that a tag single nucleotide polymorphism (rs10235235), which maps to the CYP3A locus (7q22.1), was associated with a reduction in premenopausal urinary estrone glucuronide levels and a modest reduction in risk of breast cancer in women age ≤50 years. Methods We further investigated the association of rs10235235 with breast cancer risk in a large case control study of 47,346 cases and 47,570 controls from 52 studies participating in the Breast Cancer Association Consortium. Genotyping of rs10235235 was conducted using a custom Illumina Infinium array. Stratified analyses were conducted to determine whether this association was modified by age at diagnosis, ethnicity, age at menarche or tumor characteristics. Results We confirmed the association of rs10235235 with breast cancer risk for women of European ancestry but found no evidence that this association differed with age at diagnosis. Heterozygote and homozygote odds ratios (ORs) were OR = 0.98 (95% CI 0.94, 1.01; P = 0.2) and OR = 0.80 (95% CI 0.69, 0.93; P = 0.004), respectively (Ptrend = 0.02). There was no evidence of effect modification by tumor characteristics. rs10235235 was, however, associated with age at menarche in controls (Ptrend = 0.005) but not cases (Ptrend = 0.97). Consequently the association between rs10235235 and breast cancer risk differed according to age at menarche (Phet = 0.02); the rare allele of rs10235235 was associated with a reduction in breast cancer risk for women who had their menarche age ≥15 years (ORhet = 0.84, 95% CI 0.75, 0.94; ORhom = 0.81, 95% CI 0.51, 1.30; Ptrend = 0.002) but not for those who had their menarche age ≤11 years (ORhet = 1.06, 95% CI 0.95, 1.19, ORhom = 1.07, 95% CI 0.67, 1.72; Ptrend = 0.29). Conclusions To our knowledge rs10235235 is the first single nucleotide polymorphism to be associated with both breast cancer risk and age at menarche consistent with the well-documented association between later age at menarche and a reduction in breast cancer risk. These associations are likely mediated via an effect on circulating hormone levels.

Published
2014

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