Search

Your search keyword '"Alexis Jiaying Khng"' showing total 2 results
Start Over Author "Alexis Jiaying Khng" Journal breast cancer research and treatment
2 results on '"Alexis Jiaying Khng"'

1. DNA methylation and breast cancer-associated variants

Author

Swee Ho Lim, Patrick M. Y. Chan, Siau Wei Tang, Yirong Sim, Qing Ting Tan, Mikael Hartman, Benita Kiat Tee Tan, Zhiyan Yan, Joanne Ngeow, Ern Yu Tan, Seeu Si Ong, Su-Ming Tan, Juliana Chen Jia Chuan, Rajkumar Dorajoo, Alexis Jiaying Khng, Veronique Kiak Mien Tan, Peh Joo Ho, Ivna Ivanković, Jingmei Li, and Ching Wan Chan

Subjects
0301 basic medicine, Genetics, Cancer Research, Candidate gene, dNaM, Genome-wide association study, Biology, Quantitative trait locus, medicine.disease, Minor allele frequency, 03 medical and health sciences, 030104 developmental biology, 0302 clinical medicine, Breast cancer, Oncology, 030220 oncology & carcinogenesis, DNA methylation, Expression quantitative trait loci, medicine
Abstract

A breast cancer polygenic risk score (PRS) comprising 313 common variants reliably predicts disease risk. We examined possible relationships between genetic variation, regulation, and expression to clarify the molecular alterations associated with these variants. Genome-wide methylomic variation was quantified (MethylationEPIC) in Asian breast cancer patients (1152 buffy coats from peripheral whole blood). DNA methylation (DNAm) quantitative trait loci (mQTL) mapping was performed for 235 of the 313 variants with minor allele frequencies > 5%. Stability of identified mQTLs (p

Published
2021
Full Text
View/download PDF

2. DNA methylation and breast cancer-associated variants

Author

Peh Joo, Ho, Rajkumar, Dorajoo, Ivna, Ivanković, Seeu Si, Ong, Alexis Jiaying, Khng, Benita Kiat-Tee, Tan, Veronique Kiak Mien, Tan, Swee Ho, Lim, Ern Yu, Tan, Su-Ming, Tan, Qing Ting, Tan, Zhiyan, Yan, Joanne, Ngeow, Yirong, Sim, Patrick, Chan, Juliana Chen Jia, Chuan, Ching Wan, Chan, Siau Wei, Tang, Mikael, Hartman, and Jingmei, Li

Subjects
Multifactorial Inheritance, Adolescent, Quantitative Trait Loci, Humans, Breast Neoplasms, Female, DNA Methylation, Middle Aged, Child, Polymorphism, Single Nucleotide, Genome-Wide Association Study
Abstract

A breast cancer polygenic risk score (PRS) comprising 313 common variants reliably predicts disease risk. We examined possible relationships between genetic variation, regulation, and expression to clarify the molecular alterations associated with these variants.Genome-wide methylomic variation was quantified (MethylationEPIC) in Asian breast cancer patients (1152 buffy coats from peripheral whole blood). DNA methylation (DNAm) quantitative trait loci (mQTL) mapping was performed for 235 of the 313 variants with minor allele frequencies 5%. Stability of identified mQTLs (p 5e-8) across lifetime was examined using a public mQTL database. Identified mQTLs were also mapped to expression quantitative trait loci (eQTLs) in the Genotype-Tissue Expression Project and the eQTLGen Consortium.Breast cancer PRS was not associated with DNAm. A higher proportion of significant cis-mQTLs were observed. Of 822 significant cis-mQTLs (179 unique variants) identified in our dataset, 141 (59 unique variants) were significant (p 5e-8) in a public mQTL database. Eighty-six percent (121/141) of the matched mQTLs were consistent at multiple time points (birth, childhood, adolescence, pregnancy, middle age, post-diagnosis, or treatment). Ninety-three variants associated with DNAm were also cis-eQTLs (35 variants not genome-wide significant). Multiple loci in the breast cancer PRS are associated with DNAm, contributing to the polygenic nature of the disease. These mQTLs are mostly stable over time.Consistent results from DNAm and expression data may reveal new candidate genes not previously associated with breast cancer.

Published
2020

Catalog

Books, media, physical & digital resources
See catalog results