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Start Over Author "Bouma, J.M." Journal breast cancer research and treatment
1 results on '"Bouma, J.M."'

1. The influence on quality of life of intermittent scheduling in first- and second-line chemotherapy of patients with HER2-negative advanced breast cancer

Author

Claessens, A.K.M. (Anouk K. M.), Timman, R. (Reinier), Busschbach, J.J. (Jan) van, Bouma, J.M. (Jeanette M.), Rademaker-Lakhai, J.M. (Jeany M.), Erdkamp, F.L.G. (Frans ), Tjan-Heijnen, V.C.G. (Vivianne), Bos, M.E.M.M. (Monique E. M. M.), Claessens, A.K.M. (Anouk K. M.), Timman, R. (Reinier), Busschbach, J.J. (Jan) van, Bouma, J.M. (Jeanette M.), Rademaker-Lakhai, J.M. (Jeany M.), Erdkamp, F.L.G. (Frans ), Tjan-Heijnen, V.C.G. (Vivianne), and Bos, M.E.M.M. (Monique E. M. M.)

Abstract

Background: The Stop&Go study randomized patients with advanced breast cancer to intermittent (two times four) or continuous (eight subsequent cycles) first- and second-line chemotherapy. Methods: QoL was measured with RAND-36 questionnaires every 12 weeks. The primary objective was to estimate differences in changes from baseline between intermittent and continuous treatment. An effect size of 0.5 SD (5 points) was considered clinically meaningful. Results: A total of 398 patients were included with a median follow-up of 11.4 months (IQR 5.6–22.2). Mean physical QoL baseline scores were 38.0 resp. 38.2, and mental scores 45.0 resp. 42.4 for intermittent and continuous treatme

Published
2019
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