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Your search keyword '"Jagsi, Reshma"' showing total 22 results
Start Over Author "Jagsi, Reshma" Journal breast cancer research and treatment
22 results on '"Jagsi, Reshma"'

1. Current clinical practice in the management of phyllodes tumors of the breast: an international cross-sectional study among surgeons and oncologists

Author

Sars, Carl, Sackey, Helena, Frisell, Jan, Dickman, Paul W., Karlsson, Fredrik, Kindts, Isabelle, Marta, Gustavo Nader, Freitas-Junior, Ruffo, Tvedskov, Tove Filtenborg, Kassem, Loay, Ali, Ahmed S., Ihalainen, Hanna, Neron, Mathias, Kontos, Michalis, Kaidar-Person, Orit, Meattini, Icro, Francken, Anne Brecht, van Duijnhoven, Frederieke, Moberg, Ingvild Ona, Marinko, Tanja, Kollar, Attila, Ahmed, Mahbubl, Remoundos, Dennis, Banks, Jenny, Jagsi, Reshma, Dossett, Lesly A., and Lindqvist, Ebba K.

Published
2023
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2. A qualitative study to evaluate physician attitudes regarding omission of surgery among exceptional responders to neoadjuvant systemic therapy for breast cancer (NRG-CC006)

Author

Gharzai, Laila A, Szczygiel, Lauren A, Shumway, Dean A, Bandos, Hanna, Julian, Thomas B, Mamounas, Eleftherios P, White, Julia, De Los Santos, Jennifer F, Basik, Mark, Ganz, Patricia A, and Jagsi, Reshma

Subjects
Cancer, Clinical Trials and Supportive Activities, Clinical Research, Breast Cancer, 6.4 Surgery, Evaluation of treatments and therapeutic interventions, Attitude, Breast Neoplasms, Female, Humans, Mastectomy, Segmental, Neoadjuvant Therapy, Physicians, Qualitative, De-escalation, Lumpectomy omission, Clinical Sciences, Oncology and Carcinogenesis, Oncology & Carcinogenesis
Abstract

PurposeAccrual to clinical trials that challenge well-established treatment paradigms represents a unique challenge. Physician opinions on investigation of a novel approach to breast cancer treatment, in which patients with complete response to neoadjuvant chemotherapy are offered omission of lumpectomy, are unknown. NRG-CC006 sought to describe physician attitudes toward a novel approach to breast cancer treatment.MethodsWe recruited 18 participants in the fields of surgery, medical oncology, and radiation oncology to participate in the semi-structured telephone interviews. Main outcomes are qualitative themes associated with omission of surgery.ResultsOf 18 interview participants, specialty and gender were evenly represented across surgery, medical oncology, and radiation oncology. Qualitative themes included general attitudes toward treatment de-escalation, stakeholder considerations, and trial/protocol considerations. The vast majority of participants expressed interest in investigation of omission of surgery, with all participants endorsing need for further investigation into treatment de-escalation. Stakeholder considerations in opening such a trial emphasized need for multidisciplinary involvement and, particularly, the unique role of surgeons as gatekeepers in breast cancer treatment. Finally, participants endorsed a need for further foundational studies to develop ways to predict complete pathologic response to chemotherapy without surgical intervention.ConclusionsPhysicians expressed interest in investigating a novel approach to breast cancer treatment that would omit surgery in complete responders to neoadjuvant chemotherapy. Multidisciplinary input, and specifically surgeon engagement, will be key to the success of future investigations. Ongoing work to develop approaches to predict pathologic complete response accurately is needed to achieve the promise of this idea. ClinTrials #: BR005: NCT03188393 June 13, 2017.

Published
2021

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