1. Risk scoring system for predicting breast conservation after neoadjuvant chemotherapy.
- Author
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Ouldamer L, Bendifallah S, Pilloy J, Arbion F, Body G, Brisson C, Lavoué V, Lévêque J, and Daraï E
- Subjects
- Adult, Aged, Aged, 80 and over, Area Under Curve, Breast Neoplasms mortality, Breast Neoplasms pathology, Female, Humans, Logistic Models, Middle Aged, Neoadjuvant Therapy, Neoplasm Recurrence, Local, Patient Selection, Reproducibility of Results, Risk Assessment methods, Young Adult, Breast Neoplasms drug therapy, Breast Neoplasms surgery, Mastectomy, Segmental
- Abstract
We developed a risk scoring system (RSS) for predicting breast conservative surgery (BCS) in women receiving neoadjuvant chemotherapy(NAC) for breast cancer. BCS rate in the training set was 32.6%, associated with five variables: age < 50years, primary radiological tumor diameter < 60mm, absence of multifocality, absence of breast inflammation and hormone receptor status. These variables were assigned scores ranging from 0 to 9. The discrimination of the RSS was 0.78(95%CI 0.69-0.86) in the training set. The area under the curve of the receiver operating characteristics for predicting BCS after internal and external validation was 0.77(95%CI 0.68-0.85) and 0.75(95%CI 0.66-0.84), respectively., (© 2019 Wiley Periodicals, Inc.)
- Published
- 2019
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