Huang, Yu-Xi, Wang, Wen-Xiao, Tang, Yu-Ping, and Yue, Shi-Jun
Subjects
COVID-19, COVID-19 pandemic, PHARMACOLOGY, PANDEMICS, VITAMIN C
Abstract
The outbreak and pandemic of SARS-CoV-2 in 2019 has caused a severe public health burden and will challenge global health for the future. The discovery and mechanistic investigation of drugs against Coronavirus disease 2019 (COVID-19) is in deadly demand. The paper published by Li and colleagues proposed the hypothesis that vitamin C combined with glycyrrhizic acid in treating COVID-19 and its mechanistic investigation was performed by a database-based network pharmacology. In this letter, we present critical comments on the limitations and insufficiencies involved, from both the perspective of network pharmacology and current evidence on COVID-19. [ABSTRACT FROM AUTHOR]