1. RNA structure interactions and ribonucleoprotein processes of the influenza A virus
- Author
-
Dariusz Plewczynski, Michal Lazniewski, and Wayne Dawson
- Subjects
0301 basic medicine ,Paper ,viral ribonucleoproteins ,Genome, Viral ,Biology ,RNA viral replication ,medicine.disease_cause ,Biochemistry ,Virus ,Nucleic acid secondary structure ,03 medical and health sciences ,VP40 ,Viral entry ,Transcription (biology) ,negative-strand RNA virus ,Influenza, Human ,Genetics ,Influenza A virus ,medicine ,Humans ,Molecular Biology ,Ribonucleoprotein ,RNA ,General Medicine ,Virology ,RNA and RNA/RNA interactions ,3. Good health ,030104 developmental biology ,Ribonucleoproteins ,Nucleic Acid Conformation ,RNA, Viral ,RNA viral transcription - Abstract
In one more years, we will ‘celebrate’ an exact centenary of the Spanish flu pandemic. With the rapid evolution of the influenza virus, the possibility of novel pandemic remains ever a concern. This review covers our current knowledge of the influenza A virus: on the role of RNA in translation, replication, what is known of the expressed proteins and the protein products generated from alternative splicing, and on the role of base pairing in RNA structure. We highlight the main events associated with viral entry into the cell, the transcription and replication process, an export of the viral genetic material from the nucleus and the final release of the virus. We discuss the observed potential roles of RNA secondary structure (the RNA base-pairing arrangement) and RNA/RNA interactions in this scheme.
- Published
- 2017