1. Monocyte/granulocyte to lymphocyte ratio and the MELD score as predictors for early recurrence of hepatocellular carcinoma after trans-arterial chemoembolization
- Author
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Khaled Farid, Mohamed Abd El-Maksoud, Tarek Besheer, Ayman Z. Elsamanoudy, Ali H. Elmokadem, Ahmed M. Abd El-khalek, Ahmad El-Morsy, Mahmoud El-Bendary, A M El Nakib, Hatem Elalfy, Mohamed Elegezy, and M A El-Aziz
- Subjects
Microbiology (medical) ,Adult ,Blood Platelets ,Male ,medicine.medical_specialty ,Cirrhosis ,Carcinoma, Hepatocellular ,Neutrophils ,Lymphocyte ,medicine.medical_treatment ,Clinical Biochemistry ,Immunology ,Liver transplantation ,Microbiology ,Gastroenterology ,Monocytes ,03 medical and health sciences ,Liver disease ,0302 clinical medicine ,Internal medicine ,Carcinoma ,medicine ,Immunology and Allergy ,Humans ,Lymphocyte Count ,Lymphocytes ,Chemoembolization, Therapeutic ,Aged ,Receiver operating characteristic ,business.industry ,Biochemistry (medical) ,Liver Neoplasms ,Red blood cell distribution width ,Middle Aged ,medicine.disease ,Prognosis ,body regions ,Infectious Diseases ,medicine.anatomical_structure ,030220 oncology & carcinogenesis ,Hepatocellular carcinoma ,030211 gastroenterology & hepatology ,Female ,Neoplasm Recurrence, Local ,business ,Granulocytes - Abstract
BACKGROUND The first-line treatment option for intermediate-stage hepatocellular carcinoma is trans-arterial chemoembolization (TACE). Blood indices, such as lymphocyte/monocyte ratio (LMR), lymphocyte count, neutrophil/lymphocyte ratio (NLR), platelet/lymphocyte ratio (PLR), monocyte-granulocyte/lymphocyte ratio (MGLR) and red blood cell distribution width (RDW), are prognostic biomarkers in certain diseases. The model for end-stage liver disease (MELD) and Child-Turcotte-Pugh (CTP) scores have been designed for patients with cirrhosis waiting for liver transplantation and in patients with hepatocellular carcinoma. We hypothesized possible roles for these blood indices, and the MELD and CTP scores as predictors for early recurrence of hepatocellular carcinoma after TACE. METHODS Routine laboratory indices determined the NLR, LMR, MGLR, RDW, PLR, as well as MELD and CTP scores in 147 patients. Sensitivity and specificity of the indices for hepatocellular carcinoma recurrence 36 months after TACE were estimated by receiver operator characteristic curve. RESULTS In multivariate regression analysis, only male sex, the lymphocyte count, CTP, the MGLR and the MELD score significantly (P
- Published
- 2018