1. Inhibition of angiogenesis and murine tumour growth by laminarin sulphate
- Author
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J. Donaldson, D.H. Paper, R. Hoffman, and H. Vogl
- Subjects
Cancer Research ,Angiogenesis ,Basic fibroblast growth factor ,Molecular Sequence Data ,Neovascularization, Physiologic ,Antineoplastic Agents ,Chick Embryo ,Biology ,Models, Biological ,Neovascularization ,chemistry.chemical_compound ,Laminarin ,Mice ,In vivo ,Laminin ,Polysaccharides ,medicine ,Animals ,Fibrosarcoma ,Cells, Cultured ,Matrigel ,Mice, Inbred C3H ,Neovascularization, Pathologic ,medicine.disease ,bacterial infections and mycoses ,Molecular biology ,Drug Combinations ,Oncology ,chemistry ,Carbohydrate Sequence ,Immunology ,biology.protein ,Cattle ,Proteoglycans ,Collagen ,Endothelium, Vascular ,medicine.symptom ,Research Article - Abstract
LAM S5 is a polysulphated derivative of the glucan laminarian that inhibits basic fibroblast growth factor (bFGF) binding and the bFGF-stimulated proliferation of fetal bovine heart endothelial (FBHE) cells. This report demonstrates that LAM S5 has anti-angiogenic activity, as shown by inhibition of tubule formation by endothelial cells cultured on Matrigel and inhibition of vascularisation of the chick chorioallantoic membrane. In addition, LAM S5 caused a tumour growth delay of the murine RIF-1 tumour of 2.6 days (P = 0.01). Images Figure 2
- Published
- 1996