1. Vitamin E intake from natural sources and head and neck cancer risk: a pooled analysis in the International Head and Neck Cancer Epidemiology consortium
- Author
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Edefonti, V, Hashibe, M, Parpinel, M, Ferraroni, M, Turati, F, Serraino, D, Matsuo, K, Olshan, AF, Zevallos, JP, Winn, DM, Moysich, K, Zhang, Z-F, Morgenstern, H, Levi, F, Kelsey, K, McClean, M, Bosetti, C, Schantz, S, Yu, G-P, Boffetta, P, Chuang, S-C, A Lee, Y-C, La Vecchia, C, and Decarli, A
- Subjects
Biomedical and Clinical Sciences ,Oncology and Carcinogenesis ,Dental/Oral and Craniofacial Disease ,Complementary and Integrative Health ,Nutrition ,Rare Diseases ,Prevention ,Digestive Diseases ,Cancer ,Adult ,Aged ,Female ,Head and Neck Neoplasms ,Humans ,Male ,Vitamin E ,head and neck cancer ,INHANCE ,laryngeal cancer ,oral and pharyngeal cancer ,vitamin E ,Public Health and Health Services ,Oncology & Carcinogenesis ,Oncology and carcinogenesis - Abstract
BackgroundEvidence for the possible effect of vitamin E on head and neck cancers (HNCs) is limited.MethodsWe used individual-level pooled data from 10 case-control studies (5959 cases and 12 248 controls) participating in the International Head and Neck Cancer Epidemiology (INHANCE) consortium to assess the association between vitamin E intake from natural sources and cancer of the oral cavity/pharynx and larynx. Adjusted odds ratios (ORs) and 95% confidence intervals (CIs) were estimated using unconditional logistic regression models applied to quintile categories of non-alcohol energy-adjusted vitamin E intake.ResultsIntake of vitamin E was inversely related to oral/pharyngeal cancer (OR for the fifth vs the first quintile category=0.59, 95% CI: 0.49-0.71; P for trend
- Published
- 2015