1. Identification of serum microRNA profiles in colon cancer
- Author
-
Hans H. Wasmuth, Wenche Sjursen, Liv Thommesen, Jostein Johansen, Eva Hofsli, M Rye, Gerd Tranø, Ingunn Hatlevoll, and Wenche S. Prestvik
- Subjects
Oncology ,Male ,Cancer Research ,medicine.medical_specialty ,Pathology ,Colorectal cancer ,Early detection ,diagnostic ,colorectal cancer ,Internal medicine ,microRNA ,medicine ,Humans ,microRNA profile ,Molecular Diagnostics ,Serum microrna ,Neoplasm Staging ,business.industry ,Case-control study ,Middle Aged ,medicine.disease ,Serum samples ,Gene expression profiling ,MicroRNAs ,Case-Control Studies ,Colonic Neoplasms ,Linear Models ,biomarker ,Female ,business ,Stage iv ,serum - Abstract
Background: microRNAs (miRNAs) exist in blood in an apparently stable form. We have explored whether serum miRNAs can be used as non-invasive early biomarkers of colon cancer. Methods: Serum samples from 30 patients with colon cancer stage IV and 10 healthy controls were examined for the expression of 375 cancer-relevant miRNAs. Based on the miRNA profile in this study, 34 selected miRNAs were measured in serum from 40 patients with stage I–II colon cancer and from 10 additional controls. Results: Twenty miRNAs were differentially expressed in serum from stage IV patients compared with controls (P
- Published
- 2013