1. Gastrointestinal side-effects of NSAIDs in the community.
- Author
-
Jones RH and Tait CL
- Subjects
- Adult, Aged, Aged, 80 and over, Dyspepsia epidemiology, England epidemiology, Female, Humans, Male, Middle Aged, Prevalence, Urban Health, Anti-Inflammatory Agents, Non-Steroidal adverse effects, Dyspepsia chemically induced
- Abstract
The prevalence of a range of gastrointestinal symptoms was compared in 1014 cases, identified in general practice, receiving chronic non-steroidal anti-inflammatory drug (NSAID) treatment and 975 matched community controls. The NSAIDs being taken included aspirin (33%), ibuprofen (17%), naproxen (11%), piroxicam (9%), indomethacin (8%), and diclofenac (7%). The 12-month prevalence of dyspepsia in cases was 46% and in controls 43%, with no differences in symptoms prevalence between those taking aspirin and other NSAIDs or between individual NSAIDs. About one-third of the cases had consulted a GP about their symptoms and 7% had a co-prescription for an H2-receptor antagonist. Lower-bowel symptoms were more common in the NSAID-taking cases, particularly constipation and straining, and constipation was a more common reason for stopping medication than dyspepsia.
- Published
- 1995