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Your search keyword '"Aleksandar L. Krunic"' showing total 3 results
Start Over Author "Aleksandar L. Krunic" Journal british journal of dermatology
3 results on '"Aleksandar L. Krunic"'

2. Refractory aggressive keratoacanthoma centrifugum marginatum of the scalp controlled with the epidermal growth factor receptor inhibitor erlotinib

Author

A.S. Cetner, T.K. Bulj, Aleksandar L. Krunic, and J.L. Villano

Subjects
medicine.medical_specialty, Keratoacanthoma, biology, business.industry, Squamous Cell Neoplasm, Dermatology, medicine.disease, chemistry.chemical_compound, Endocrinology, chemistry, Epidermal growth factor, Internal medicine, Quinazoline, Cancer research, biology.protein, Medicine, Erlotinib, Epidermal growth factor receptor, business, Receptor, Intracellular, medicine.drug
Abstract

Summary Keratoacanthomas are squamous cell neoplasms known to be abundant in epidermal growth factor receptors (EGFRs). Erlotinib (Tarceva®; Roche) is a low molecular weight oral quinazoline compound that binds to the intracellular EGFR tyrosine kinase domain and inhibits receptor phosphorylation and downstream signalling. We report a case of refractory, locally aggressive keratoacathoma centrifugum marginatum of the scalp having strong EGFR expression and demonstrating excellent response to erlotinib.

Published
2010
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